Assisted Reproductive Technologies and imprinting disorders: Results of a study from a French congenital malformations registry

European Journal of Medical Genetics
Audrey UkEmmanuelle Amar

Abstract

Assisted Reproductive Technologies (ART) is increasingly used to help infertile couples to have children around the world. A number of studies have been published reporting an increased risk of major malformations in children born following ART, especially an increased incidence of epigenetic diseases (ED). This study aimed to assess the incidence of epigenetic diseases with affected imprinting genes in infants or children from pregnancies obtained through IVF/ICSI compared to infants or children from pregnancies obtained spontaneously. This is a monocentric retrospective epidemiological study based on data from a French congenital malformations registry called REMERA (Registre des Malformations en Rhône-Alpes) which exhaustively monitors all pregnancies in Rhone-Alpes region, whatever their nature of onset (spontaneous pregnancies or pregnancies from ART). This registry collects all malformations, except minor malformations (EUROCAT), and all polymalformative syndromes concerning all fetuses and children born alive or not, from 20 weeks of pregnancy (or 22 weeks of amenorrhea) and all medical termination of pregnancy whatever the term. Inclusion criteria are all diagnoses of epigenetic diseases (ED) related to parental imprint...Continue Reading

Citations

Feb 15, 2020·Molecular Human Reproduction·Christine Leary, Roger G Sturmey
Aug 25, 2018·Molecular Cytogenetics·Xiangyu ZhuYali Hu
May 10, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Jul 28, 2020·International Journal of Molecular Sciences·Huixia YangViktoria von Schönfeldt
Feb 9, 2019·Clinical Epigenetics·Hiromitsu HattoriTakahiro Arima
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Haibo ZhuQi Zhou
Aug 28, 2021·International Journal of Molecular Sciences·Huixia YangViktoria von Schönfeldt
Nov 6, 2021·American Journal of Obstetrics and Gynecology·UNKNOWN Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.orgUNKNOWN Publications Committee

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