Associated and predictive factors of quality of life in patients with temporal lobe epilepsy

Epilepsy & Behavior : E&B
Ya-Yu ChenBo Xiao

Abstract

Identifying the factors that are correlated with and predictive of reduced quality of life (QOL) is essential to optimize the treatment of epilepsy and the management of comorbidities. We analyzed the independent associations between the Quality of Life in Epilepsy-31 (QOLIE-31) inventory and the demographic, clinical, psychiatric, and cognitive variables of 47 consecutive patients with temporal lobe epilepsy (TLE). Predictors of the correlated variables were analyzed by multiple linear regression analysis. The QOLIE-31 total score was positively correlated with occupational status and Mini-Mental State Examination (MMSE) scores (r = 0.290 and 0.295, respectively; P < 0.05) and negatively correlated with the duration of seizures, adverse effects of antiepileptic drugs (AEDs), and the Pittsburgh Sleep Quality Inventory (PSQI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) scores (r = -0.357, 0.321, 0.328, -0.672, and -0.565, respectively; P < 0.05; P < 0.01 for the SAS and SDS). In the final multivariate regression model, anxiety, long durations of seizures, adverse effects of AEDs, and depression explained approximately 60.6% (adjusted R2 = 0.606, R coefficient = 0.800) of the QOLIE-31 overall score va...Continue Reading

Citations

Apr 23, 2020·British Journal of Pharmacology·Pabitra Hriday PatraAlister James McNeish
Aug 16, 2019·Journal of Neurology·Robert QuonBarbara Jobst
Apr 20, 2019·Epilepsy & Behavior : E&B·Tyler E GastonUNKNOWN UAB CBD Program
Apr 11, 2021·Seizure : the Journal of the British Epilepsy Association·Ellen Marise LimaKette Dualibi Ramos Valente
Sep 16, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alicia Gonzalez-MartinezMaría De Toledo-Heras

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