Associated inflammatory response in pneumonia: role of adjunctive therapy with glucocorticoids

Current Opinion in Infectious Diseases
Ana RañóAntoni Torres

Abstract

This article reviews the potential use of glucocorticoids as adjunctive therapy in the management of patients with severe bacterial pneumonia or pulmonary infections of other etiologies. The importance of an adequate assessment of the inflammatory process and the appearance of inflammatory markers that correlate with the severity of pneumonia is underlined. A recent randomized clinical trial indicates that adjunctive treatment of severe community-acquired pneumonia with glucocorticoids reduces complications and improves survival. The role of glucocorticoids in other lung infections is also reviewed. The design of new compounds with similar anti-inflammatory properties to classical glucocorticoids but with significantly fewer side effects constitutes a specific challenge for the near future. Although adjunctive treatment with glucocorticoids in severe pneumonia is probably indicated, further randomized clinical trials are urgently needed to confirm the preliminary positive results. In this regard, a proper evaluation of the inflammatory response is likely to be essential for the accurate selection of the target population.

References

Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·M S DehouxM Aubier
Oct 3, 1999·Critical Care Medicine·C MontónJ P de la Bellacasa
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·M A Jantz, S A Sahn
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Nov 12, 2002·American Journal of Respiratory and Critical Care Medicine·Didier KehHerwig Gerlach
Jun 11, 2003·Chest·Samuel Z Goldhaber
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Silvia Fernández-SerranoFrederic Manresa
Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Heike SchäckeKhusru Asadullah
Jan 14, 2004·Chest·P S SriramJohn G Mastronarde
Apr 9, 2004·Critical Care Medicine·Malina IoanasAntoni Torres
Apr 14, 2004·Chest·Jordi AlmirallUNKNOWN Community-Acquired Pneumonia Maresme Study Group
Jul 2, 2004·American Journal of Respiratory and Critical Care Medicine·Wouter MeerssemanEric Van Wijngaerden
Jul 24, 2004·Infection and Immunity·Yuanchun ZhangJinning Lou
Sep 24, 2004·Current Opinion in Critical Care·Francisco Alvarez-Lerma, Antoni Torres
Oct 12, 2004·The Journal of Infection·V C C ChengK Y Yuen
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Marco ConfalonieriG Umberto Meduri
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Mitchell M LevyUNKNOWN Institute of Allergy and Infectious Diseases
Feb 18, 2005·The Journal of Infectious Diseases·Harriet Mayanja-KizzaUNKNOWN Uganda-Case Western Research Collaboration
Jun 28, 2005·The Lancet Infectious Diseases·Surendra Kumar SharmaDipendra Kumar Mitra
Sep 17, 2005·American Journal of Respiratory and Critical Care Medicine·Sachin YendeStephen B Kritchevsky
Sep 22, 2005·Current Opinion in Critical Care·Djillali Annane

❮ Previous
Next ❯

Citations

Feb 15, 2008·The New England Journal of Medicine·Joseph P Mizgerd
Mar 17, 2011·Critical Care : the Official Journal of the Critical Care Forum·Silvia Fernández-SerranoFrederic Manresa
Dec 24, 2013·Mediators of Inflammation·Felinda ArianiJieming Qu
Nov 28, 2012·Therapeutic Advances in Respiratory Disease·Adriel MalaveMarcos I Restrepo
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Luis A DíazMarcos I Restrepo
Jan 25, 2020·Hospital Practice·David NoraPedro Póvoa
Dec 14, 2011·Current Opinion in Infectious Diseases·Pedro Póvoa, Jorge I F Salluh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

American Journal of Respiratory and Critical Care Medicine
A BouttenM Aubier
American Journal of Respiratory and Critical Care Medicine
M S DehouxM Aubier
American Journal of Respiratory and Critical Care Medicine
Marco ConfalonieriG Umberto Meduri
© 2021 Meta ULC. All rights reserved