Associated reactions during and immediately after rtPA infusion

Annals of Emergency Medicine
W LinnikR Ramos

Abstract

The complications of IV recombinant tissue-type plasminogen activator (rtPA) have not been previously reported specifically for the first hours after initiation of the therapy when patients are often in emergency departments or in transport. The charts of 124 patients who received rtPA between April 1986 and December 1987 were retrospectively reviewed for reactions associated with rtPA infusion occurring in the first ten hours after the onset of rtPA administration. Minor bleeding developed in 19% of the patients, and life-threatening bleeding in 3%. Half of the life-threatening bleeding episodes were not predictable by history or physical examination. Arrhythmias were frequent despite the fact that all patients were maintained on IV lidocaine. New premature ventricular contractions occurred in 67%, accelerated idioventricular rhythm in 34%, ventricular tachycardia in 30%, and ventricular fibrillation in 2%. Many of the arrhythmias other than ventricular fibrillation had little hemodynamic consequence and did not require treatment. Neurologic episodes occurred in 3%, including two patients with intracerebral bleeding (1.5%); hypotension requiring treatment developed in 3%; and minor symptoms of allergy in 2%. Administration of ...Continue Reading

References

Feb 1, 1988·Journal of the American College of Cardiology·J W KennedyW D Weaver
Nov 1, 1987·American Heart Journal·M W Rich
Nov 1, 1984·Neurology·M S KomradR M Califf

❮ Previous
Next ❯

Citations

May 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A BersanoP L Baron
Aug 31, 2006·The Journal of Experimental Medicine·Ulrich SchaeferRoberto Levi
Jan 1, 1993·Intensive Care Medicine·F Guerrero LópezP Aranegui Lasuen
Sep 14, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·C PechlanerC J Wiedermann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
G A Wilkinson, W G Williams
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
H Y KaragozK Bayazit
Journal of Molecular and Cellular Cardiology
A M Dart, R A Riemersma
© 2022 Meta ULC. All rights reserved