Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment

Current Protocols in Toxicology
Jamie C DeWittVictor J Johnson

Abstract

This overview is an update of the unit originally published in 2004. While the basic tenets of immunotoxicity have not changed in the past 10 years, several publications have explored the application of immunotoxicological data to the risk assessment process. Therefore, the goal of this unit is still to highlight relationships between xenobiotic-induced immunosuppression and risk of clinical diseases progression. In immunotoxicology, this may require development of models to equate moderate changes in markers of immune functions to potential changes in incidence or severity of infectious diseases. For most xenobiotics, exposure levels and disease incidence data are rarely available, and safe exposure levels must be estimated based on observations from experimental models or human biomarker studies. Thus, it is important to establish a scientifically sound framework that allows accurate and quantitative interpretation of experimental or biomarker data in the risk assessment process.

References

Oct 1, 1979·Psychosomatic Medicine·S V KaslJ C Niederman
Mar 1, 1978·American Journal of Diseases of Children·J Deseda-TousE W Walbergh
Aug 29, 1991·The New England Journal of Medicine·S CohenA P Smith
Mar 1, 1990·Transplantation·M M HarteveltJ P Vandenbroucke
Mar 1, 1987·Brain, Behavior, and Immunity·R GlaserM Beck
Feb 1, 1986·Journal of Behavioral Medicine·J K Kiecolt-GlaserC E Speicher
Jan 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterJ H Dean
Jan 1, 1986·The Journal of Pediatrics·C B Wilson
Sep 1, 1987·Psychosomatic Medicine·J K Kiecolt-GlaserC E Speicher
Jan 1, 1983·Journal of the American Geriatrics Society·T T Yoshikawa
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·F B GearaA Pollack
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·S Cohen
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·P S ThomasP J Barnes
Jan 1, 1994·Journal of Perinatal Medicine·F Ciccimarra
Nov 1, 1993·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·R GlaserJ K Kiecolt-Glaser
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterW Craig
Aug 1, 1995·Computer Methods and Programs in Biomedicine·R Othman
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·J K Kiecolt-GlaserJ Sheridan
Jun 28, 1996·Journal of Toxicology and Environmental Health·T VialJ Descotes
Aug 1, 1997·The American Journal of Clinical Nutrition·B M Lesourd
Jan 7, 1998·Journal of Applied Toxicology : JAT·H TuschlR Kovac
Apr 9, 1998·The Surgical Clinics of North America·I G Sia, C V Paya
Nov 26, 1998·Chemosphere·M L YuY L Guo
May 27, 1999·The Proceedings of the Nutrition Society·B Lesourd
Sep 30, 1999·Environmental Health Perspectives·V ArndtK Weigle
Mar 8, 2000·Environmental Health Perspectives·E DewaillyR Roy
Aug 5, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E V Yang, R Glaser
Aug 17, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I Penn
Jan 3, 2001·Environmental Health Perspectives·M F VineL Backer
Jan 3, 2001·Environmental Health Perspectives·N Weisglas-KuperusH Hooijkaas
Jan 4, 2001·Psychosomatic Medicine·R GlaserJ K Kiecolt-Glaser
Feb 13, 2001·American Journal of Epidemiology·M F VineL Backer
Mar 27, 2001·Toxicology and Applied Pharmacology·B YucesoyM I Luster
Jun 19, 2001·Geriatric Nursing·A S Luggen
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A Kauffman
Jul 31, 2001·European Journal of Pediatrics·H Faden
Aug 17, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S A GrimbleR B Galland

❮ Previous
Next ❯

Citations

Nov 30, 2018·Journal of Exposure Science & Environmental Epidemiology·Jamie C DeWittLaurel A Schaider
Jan 1, 2021·PloS One·Philippe GrandjeanKåre Mølbak
Apr 4, 2021·International Journal of Environmental Research and Public Health·Olga V NaidenkoSean Perrone-Gray
Aug 9, 2021·Journal of Ayurveda and Integrative Medicine·Gunjan Y Trivedi, Banshi Saboo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved