Association among Fas expression in leucocytes, serum Fas and Fas-ligand concentrations and hepatic inflammation and fibrosis in chronic hepatitis C

Liver International : Official Journal of the International Association for the Study of the Liver
Anatol PanasiukRobert Flisiak

Abstract

Replication of the hepatitis C virus (HCV) in peripheral blood mononuclear cells (PBMC) may impair immune functions and establish persistent infection. The aim of this study was to assess the influence of HCV on PBMC and their susceptibility to apoptosis in relation to liver inflammation and fibrosis. Eighty-one patients with chronic hepatitis C (CHC) were enrolled in this study. Flow cytometry was used to determine the amount of T cells (CD4(+), CD8(+)), B cells (CD19(+)), monocytes (CD14(+)) and natural killer cells (CD16(+)) in the peripheral blood and the expression of CD95(+) (CD95/APO-1) in each subset. Serum concentrations of sFas and sFasL were assessed by the enzyme-linked immunosorbent assay method. An increased expression of Fas was observed in CD4(+) and CD8(+) cells in CHC. There was a more prominent expression of Fas on CD4(+) cells in HCV genotype 1b in contrast to 3a. Increased Fas expression on CD4(+) cells was seen in advanced stages of liver disease. Fas expression on monocytes was lower in advanced stages of liver inflammation and fibrosis. Serum sFas concentration was higher in CHC compared with the control group. There was an association between sFasL concentration and inflammatory activity in the liver. S...Continue Reading

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Citations

Jul 26, 2011·Comparative Hepatology·Abdel-Rahman N ZekriSayed S Daoud
Aug 29, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Anna Parfieniuk-KowerdaRobert Flisiak
Jan 7, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel Pineda-TenorSalvador Resino
Jan 29, 2016·World Journal of Gastroenterology : WJG·Pamela ValvaMaria V Preciado
Aug 11, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Baila SamreenShah Jahan

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