Abstract
Chronic urticaria (CU) is an immune-mediated disease characterized by wheals for at least 6 weeks. The role of stress and the correlation of stress, hypocortisolism, and inflammatory markers are not well understood. To estimate C-reactive protein (CRP), interleukin (IL)-18, and cortisol levels in patients with CU and to explore their association with disease severity and stress. Forty-five patients with CU and 45 age- and sex-matched healthy controls were recruited for this cross-sectional study. Disease severity was assessed by the urticaria activity score (UAS) and stress by Presumptive Stressful Life Events (PSLE) and Daily Hassles and Uplifts Scale-Revised (DHUS-R) scoring. IL-18 and high-sensitivity CRP (hs-CRP) were estimated using enzyme-linked immunosorbent assay kits and cortisol levels by chemiluminescence. We observed significant systemic inflammation (increased hs-CRP and IL-18 levels) and stress scores, whereas there was a lowering of basal cortisol levels in patients with CU compared with controls. This finding was more pronounced with increasing disease severity and autoimmune disease, except for stress scores, which did not vary between patients with positive and negative autologous plasma skin test results. We ...Continue Reading
References
Sep 1, 1985·The American Journal of Psychiatry·L J Siever, K L Davis
Mar 1, 1981·Journal of Behavioral Medicine·A D KannerR S Lazarus
Sep 1, 1980·The British Journal of Medical Psychology·G A FavaC V Fornasa
Jul 15, 1996·Biological Psychiatry·R YehudaL J Siever
Jan 8, 1998·Endocrinology·T C TheoharidesG Chrousos
Mar 26, 1998·Brain, Behavior, and Immunity·F S Dhabhar, B S McEwen
Nov 22, 2005·The Journal of Investigative Dermatology·Nikoletta PapadopoulouTheoharis C Theoharides
Jan 27, 2006·Allergy·T ZuberbierB Wedi
May 6, 2006·The Journal of Allergy and Clinical Immunology·Riccardo AseroMassimo Cugno
Jan 20, 2007·The Journal of Investigative Dermatology·Hyun Jeong ParkDae Ho Cho
Jul 27, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mine OzkanBahattin Colakoğlu
Jul 9, 2008·Psychosomatic Medicine·Zenon BrzozaBarbara Rogala
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology·Agnieszka MłynekAnna Zalewska
Dec 5, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A Kasperska-ZajacJ Jochem
Feb 26, 2013·Cytokine·I PuxedduP Migliorini
Mar 7, 2013·Acta Dermato-venereologica·Jung Eun KimHyun Jeong Park
Apr 25, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Medha RajappaPampa Ch Toi
Jul 6, 2014·TheScientificWorldJournal·Rui TianTi-Fei Yuan
Nov 8, 2014·Asia Pacific Allergy·Roohi RasoolZafar A Shah
Dec 30, 2014·Asian Pacific Journal of Allergy and Immunology·Derya UcmakMustafa Arica
Jul 15, 2015·Postȩpy dermatologii i alergologii·Sirac AktarAyse Serap Karadag
Dec 4, 2015·Clinical and Translational Allergy·Karen LindsayBrian Broom
Citations
Aug 6, 2016·Mediators of Inflammation·Urs NydeggerThomas Bodmer
Jan 18, 2018·Allergy·T ZuberbierUNKNOWN Endorsed by the following societies: AAAAI, AAD, AAIITO, ACAAI, AEDV, APAAACI, ASBAI, ASCIA, BAD, BSACI, CDA, CMICA, CSACI,
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ciara Jade Bansal, Amolak Singh Bansal
Jun 25, 2019·Medicine·Leixiao ZhangYing Li
Mar 11, 2020·Frontiers in Cellular and Infection Microbiology·Detong WangHongzhou Cui
Aug 26, 2018·Medicine·Guan-Yi HeTai-Yi Hsu
Jul 24, 2020·Journal of Neurodevelopmental Disorders·Sarika U PetersDouglas A Granger
Nov 28, 2018·Allergy, Asthma & Immunology Research·Ji Ho LeeYoung Min Ye
Dec 8, 2020·Allergy·Emek KocatürkMarcus Maurer
Feb 10, 2021·Antibiotics·Jun WatanabeKazuhiko Kotani
May 19, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Łukasz MoosZenon Brzoza
Sep 28, 2021·The World Allergy Organization Journal·Catherine KingNiall Conlon
Sep 19, 2021·Allergy·Torsten ZuberbierMarcus Maurer
Jan 28, 2020·Actas dermo-sifiliográficas·M Alcántara VillarR Ruiz-Villaverde