Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
Wei TangWeidong Tian

Abstract

To investigate whether an association occurred between the IRF6 G820A polymorphism and nonsyndromic cleft lip with or without cleft palate (CL+/-P) or cleft palate only (CPO) in Chinese patients. Case-controlled study at the West China Hospital of Stomatology, Sichuan University, China. A total of 91 patients with cleft lip and/or palate (CL/P) and 96 unrelated, healthy individuals with no family history of CL/P were genotyped. The IRF6 G820A polymorphism was genotyped by restriction digestion of polymerase chain reaction products with BseLI. Chi-square statistics were used to make case-controlled comparisons. The frequency of the A allele was significantly increased and the frequency of the G allele was reduced in CPO patients in comparison with control subjects. The 820GG genotype had a significantly lower frequency in patients with CPO than in controls, with an odds ratio of 0.25 (95% confidence interval, -0.061 to 0.57). No difference in the distribution of genotypes was noted between CL+/-P patients and the total group of CL/P patients compared with controls. The present findings indicate that the 820A allele is more frequent in the Chinese CPO population and may confer an increased risk for CPO in these individuals. The G...Continue Reading

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Citations

Mar 23, 2012·Journal of Applied Oral Science : Revista FOB·José Alberto de Souza FreitasJoão Henrique Nogueira Pinto
Apr 5, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·M H Rajabian, M Sherkat
Aug 28, 2010·American Journal of Medical Genetics. Part a·Yongchu PanLin Wang
Nov 19, 2009·American Journal of Medical Genetics. Part a·Katherine NeiswangerMary L Marazita
Aug 11, 2015·Journal of Oral Biology and Craniofacial Research·D Mehrotra
Aug 12, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Kachin WattanawongAmmarin Thakkinstian
Jul 30, 2015·Journal of Applied Oral Science : Revista FOB·Firoozeh RafighdoostEbrahim Eskandari-Nasab
Sep 30, 2019·Oral Diseases·Camilla de Marchi Sanches AzevedoAna Lúcia Carrinho Ayroza Rangel
Aug 27, 2019·Genetic Testing and Molecular Biomarkers·Yue XingShijie Tang
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Marcella MartinelliLuca Scapoli

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