Association analysis of genetic variants in microRNA networks and gastric cancer risk in a Chinese Han population.

Journal of Cancer Research and Clinical Oncology
Yuan ZhouXue-Jun Zhang

Abstract

To investigate associations between genetic variants involved in microRNA networks (microRNA biogenesis, microRNA and microRNA binding sites) and risk of gastric cancer. We genotyped 19 SNPs of the microRNA-related genes in a case-control study of 311 gastric cancers and 425 cancer-free controls in a Chinese Han population. We found that two of the SNPs were significantly associated with gastric cancer. Inhibitory effect of minor allele T of rs2071504 SNP within the exon of POLR2A gene was significantly associated with gastric carcinogenesis (p = 0.033, aOR = 0.742, 95%CI = 0.564-0.977) and the SNP rs895819 in the miR-27a gene with the minor allele C presented significantly reduced risk to gastric cancer (p = 0.037, aOR = 0.771, 95%CI = 0.604-0.985). Further stratified analysis with regard to clinical pathological parameters of the patients indicated that the SNP rs2071504 was associated with lymph node metastasis (p = 0.021, aOR = 0.529, 95%CI = 0.307-0.910) and TMN stage (p = 0.021, aOR = 0.532, 95%CI = 0.311-0.908), respectively. Our findings provided evidence that the SNP rs2071504 in the exon of POLR2A gene would not only confer a decreased risk of gastric cancer, but also influence lymph node metastasis and TMN stage of g...Continue Reading

References

Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Feb 21, 2006·World Journal of Gastroenterology : WJG·Katherine D Crew, Alfred I Neugut
Jul 11, 2006·Human Molecular Genetics·Philip J SmithAdrian R Krainer
Mar 14, 2007·Blood·Elizabeth S RavecheGerald E Marti
Apr 6, 2007·Endocrine Reviews·Robert R Langley, Isaiah J Fidler
Oct 19, 2007·DNA and Cell Biology·Debora LandiStefano Landi
Mar 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Madhu S KumarTyler Jacks
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Mar 19, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tian TianHongbing Shen
Oct 17, 2009·Digestive Diseases and Sciences·Sheng PengQinghong Cheng
Oct 24, 2009·Molecular Carcinogenesis·Jessica ClagueXifeng Wu
May 25, 2010·Nature Reviews. Cancer·Bríd M RyanCurtis C Harris
May 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Maximiliano M Portal
Jun 28, 2011·BMC Systems Biology·Chien-Wei TsengHsueh-Fen Juan

❮ Previous
Next ❯

Citations

Nov 19, 2013·Molecules and Cells·Xiaoxing XiongShengmei Zhu
Jul 4, 2012·Breast Cancer Research and Treatment·Rongxi Yang, Barbara Burwinkel
Apr 1, 2014·Journal of Cancer Research and Clinical Oncology·Peng SongQinghong Zhao
Jul 15, 2015·Molecular and Clinical Oncology·Cheng FangXinghua Long
May 16, 2015·Journal of Evidence-based Medicine·Lu YuanYan Ren
Apr 22, 2015·Biogerontology·Syed Aleem Haider, Muhammad Faisal
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Qian XuYuan Yuan
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Rong-Pan BaiGuang-Di Chen
Nov 17, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bo SongBei Yang
Sep 28, 2016·World Journal of Gastroenterology : WJG·Kelly Cristina da Silva OliveiraDanielle Queiroz Calcagno
Dec 26, 2012·Molecular Biology Reports·Shanliang ZhongJianhua Zhao
Apr 15, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tian TianJuncheng Dai
Nov 2, 2019·Gene·Yu WengRongpan Bai
Aug 1, 2014·Diagnostic Pathology·Zaiqiu WangSanyuan Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.