Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis.

The Journal of Veterinary Medical Science
Kazuaki TanakaMasahiro Sakaguchi

Abstract

Interleukin-4 (IL4) and interleukin-13 (IL13) are involved in the initial response of T helper 2 lymphocytes through the activation of the IL4 receptor alpha (IL4RA), which is a common receptor chain for these cytokines. In humans, several single-nucleotide polymorphisms (SNPs) identified in the IL4R and in interleukin coding genes were associated with atopic disorders. However, the association between canine IL4R polymorphisms and atopic disorders has not been investigated yet. This study aimed to determine the associations between four non-synonymous SNPs and canine atopic dermatitis (CAD) in shiba inu and miniature dachshund populations. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis were used to genotype four polymorphisms of canine IL4R and IL13 in 34 shiba inu and 19 miniature dachshund patients with CAD, as well as 29 shiba inu and 39 miniature dachshund patients without the condition. Results from miniature dachshunds revealed a potential association between the presence of minor A allele rs24378020 and CAD (odds ratio, 0.10; 95% confidence interval, 0.01-0.85; Poriginal=0.0062). This CAD resistance allele led to an amino acid substitution (Arg688Cys) that could impair IL4 a...Continue Reading

References

Dec 11, 1997·The New England Journal of Medicine·G K HersheyT A Chatila
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·J E de Vries
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Jul 15, 2000·The New England Journal of Medicine·D DupreC Ferec
Mar 22, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·M CagganaA C Walsh
Dec 13, 2001·American Journal of Human Genetics·Timothy D HowardEugene R Bleecker
Jun 7, 2003·Science·Ann E Kelly-WelchAchsah D Keegan
May 25, 2004·Science·Heidi G ParkerLeonid Kruglyak
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Weiguo ChenGurjit K Khurana Hershey
Nov 17, 2004·Genome Research·Nathan B SutterElaine A Ostrander
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Jun 12, 2009·The Journal of Investigative Dermatology·Rosanna Marsella, Giampiero Girolomoni
Apr 1, 2010·Nature Methods·Ivan A AdzhubeiShamil R Sunyaev
Oct 5, 2010·Veterinary Dermatology·Sylvia WilhemClaude Favrot
Jun 13, 2012·Nucleic Acids Research·Ngak-Leng SimPauline C Ng
Jun 23, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Z BrzozaD Moczulski
May 22, 2013·The New England Journal of Medicine·Sally WenzelGianluca Pirozzi
Jan 28, 2014·Veterinary Dermatology·Thierry OlivryUNKNOWN International Committe on Allergic Diseases of Animals (ICADA)
Jul 10, 2014·The New England Journal of Medicine·Lisa A BeckAllen R Radin
Jan 23, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W Peng, N Novak
Aug 12, 2015·BMC Veterinary Research·Patrick HenselCraig Griffin
May 27, 2017·Drugs·Matt Shirley
Nov 9, 2018·Nucleic Acids Research·Fiona CunninghamPaul Flicek
Dec 24, 2018·Database : the Journal of Biological Databases and Curation·Sarah E HuntFiona Cunningham
Jul 11, 2019·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Eva KovacsEva Grill
Apr 3, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Manaka UshidaJun Asai

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Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

PolyPhen
Ensembl genome browser
Ensembl browser
PROVEAN
PolyPhen SIFT PROVEAN
SIFT

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.