Association analysis of positional obesity candidate genes based on integrated data from transcriptomics and linkage analysis

International Journal of Obesity : Journal of the International Association for the Study of Obesity
H JiaoI Dahlman

Abstract

Obesity is a typical complex disorder resulting from behaviors promoted in westernized societies in the presence of a genetic predisposition. We hypothesized that new genes predisposing to obesity can be detected at the mRNA level. To identify susceptibility genes for obesity. Linkage and expression profile data from different cohorts were combined to select novel candidate genes that were analyzed for association with obesity. University Hospital in Stockholm. Adipose tissue mRNA levels were quantified in 96 women. Two large cohorts with a wide distribution in body mass index (BMI, n=1013 and 1423) were genotyped. mRNA levels and allelic association with obesity. We confirmed association between candidate gene mRNA levels in adipose tissue and obesity. A total of 118 polymorphisms in 16 genes were analyzed for association with obesity. Single nucleotide polymorphism rs1064891, located in the 3' UTR of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) gene, was nominally associated with obesity in combined analysis of cohorts 1 and 2 (P=0.007) and, in men that were lean or had severe obesity, with BMI (P=or<0.005). To combine linkage and expression profile data is valuable in finding new obesity genes. PFKFB3,...Continue Reading

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Citations

Mar 24, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A J WalleyP Froguel
Sep 14, 2011·Neuropsychobiology·Alicia K SmithMangalathu S Rajeevan
Oct 27, 2010·International Journal of Biological Sciences·Caode JiangShuang Luo
Jul 10, 2018·Expert Opinion on Therapeutic Targets·Ramon BartronsÀurea Navarro-Sabaté
Jan 1, 2020·G3 : Genes - Genomes - Genetics·Karen A SchlauchJoseph J Grzymski

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