Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model

Pancreas
Sumit PaliwalGiriraj Ratan Chandak

Abstract

Association of PRSS1-PRSS2 (rs10273639) and CLDN2-MORC4 (rs12688220 and rs7057398) variants with alcohol-related chronic pancreatitis (CP) is established but with nonalcoholic CP is unclear. We addressed this inconsistency using tropical calcific pancreatitis (TCP) as model. We sequenced 5'-UTR of PRSS1 and genotyped CLDN2-MORC4 variants in 555 patients with TCP and 801 controls and performed association analysis. Gene-gene interaction between PRSS1 and CLDN2-MORC4 variants and with p.Asn34Ser SPINK1 and p.Leu26Val CTSB was also evaluated. We observed significant association of rs10273639/rs4726576 in PRSS1-PRSS2 (odds ratio [OR] = 0.72; P = 3.50 × 10) and CLDN2-MORC4 variants, rs12688220 (OR = 1.54; P = 1.22 × 10) and rs7057398 (OR = 1.50; P = 1.22 × 10) with TCP. Patients carrying p.Asn34Ser SPINK1 were significantly younger than those with rs4726576 risk genotype (30.0 vs 38.0 years; P = 0.015) and those carrying both were even younger (22.0 years; P = 0.001). Presence of risk allele at rs12688220 in patients carrying p.Asn34Ser SPINK1 delayed the age of onset (32.0 vs 24.0 years; P = 0.013). Our study establishes strong association of PRSS1-PRSS2 and CLDN2-MORC4 variants with TCP and thus with nonalcoholic CP. These variant...Continue Reading

References

Sep 3, 1998·The New England Journal of Medicine·N SharerJ Braganza
Dec 5, 2003·Postgraduate Medical Journal·K K BarmanV Mohan
Aug 6, 2005·Journal of Clinical Gastroenterology·Chirag D Trivedi, C S Pitchumoni
Nov 27, 2009·Genome Medicine·David G Clayton
Jan 12, 2010·Annual Review of Medicine·David C Whitcomb
Jul 21, 2011·The Journal of Biological Chemistry·Takuya SuzukiSoichi Tanabe
Jul 4, 2012·Clinics and Research in Hepatology and Gastroenterology·Jian-Min Chen, Claude Férec
Aug 16, 2013·World Journal of Gastroenterology : WJG·Jan SödermanSven Almer
Aug 21, 2013·Nature Genetics·Heiko WittMiklós Sahin-Tóth
Sep 26, 2014·Gut·Monique H DerikxUNKNOWN PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators

❮ Previous
Next ❯

Citations

Oct 30, 2016·Journal of Cellular Physiology·Guoju HongJiake Xu
Sep 16, 2017·International Journal of Cancer. Journal International Du Cancer·Daniele CampaFederico Canzian
Jun 15, 2018·Current Opinion in Gastroenterology·Frank U WeissMarkus M Lerch
Oct 16, 2018·Journal of Cellular Biochemistry·Zi'ang YangShengkai Geng
Nov 3, 2017·Frontiers in Plant Science·Aline KochKarl-Heinz Kogel
Jul 28, 2018·Database : the Journal of Biological Databases and Curation·Garima SinghAshutosh Singh
Oct 31, 2020·Nature Communications·Adam H TencerTatiana G Kutateladze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2022 Meta ULC. All rights reserved