PMID: 9171958Jun 1, 1997Paper

Association analysis of six candidate genes in a sample of Australian hypertensive patients

Clinical and Experimental Pharmacology & Physiology
P R HuggardM J West

Abstract

1. Essential hypertension is characterized by increased vascular resistance due to narrowing of the small arterioles. This may be influenced by vasoactive substances, cell growth and vascular remodelling. 2. A sample of Australian hypertensive and normotensive subjects was investigated for association with genetic markers which are candidates for a role in blood pressure (BP) regulation due to potential effects on vascular diameter. 3. The six markers used were for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix. 4. No significant association of any of the markers used was found with BP status in this sample of patients.

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·R Y ZeeB J Morris
Nov 27, 1991·Biochemical and Biophysical Research Communications·L H YingB J Morris
Mar 1, 1994·Clinical and Experimental Pharmacology & Physiology·M J WestP R Huggard
May 1, 1994·Human Molecular Genetics·E DaviesF Soubrier

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