Association and birth prevalence of microcephaly attributable to Zika virus infection among infants in Paraíba, Brazil, in 2015-16: a case-control study

The Lancet Child & Adolescent Health
Elisabeth R Krow-LucalParaíba Microcephaly Work Group

Abstract

In 2015, the number of infants born with microcephaly increased in Paraíba, Brazil, after a suspected Zika virus outbreak. We did a retrospective case-control investigation to assess the association of microcephaly and Zika virus. We enrolled cases reported to the national database for microcephaly and born between Aug 1, 2015, and Feb 1, 2016, on the basis of their birth head circumference and total body length. We identified controls from the national birth registry and matched them to cases by location, aiming to enrol a minimum of two controls per case. Mothers of both cases and controls were asked about demographics, exposures, and illnesses and infants were measured at a follow-up visit 1-7 months after birth. We took blood samples from mothers and infants and classified those containing Zika virus IgM and neutralising antibodies as evidence of recent infection. We calculated prevalence of microcephaly and odds ratios (ORs) using a conditional logistic regression model with maximum penalised conditional likelihood, and combined these ORs with exposure probability estimates to determine the attributable risk. We enrolled 164 of 706 infants with complete information reported with microcephaly at birth, of whom we classified...Continue Reading

Citations

Mar 29, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Eliza Gordon-Lipkin, Georgina Peacock
Mar 29, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Kim KotzkyGeorgina Peacock
Oct 9, 2019·Birth Defects Research·Vanessa van der LindenCynthia A Moore
Oct 10, 2019·The New England Journal of Medicine·Didier MussoDavid Baud
Mar 12, 2019·PLoS Neglected Tropical Diseases·Priscila M S CastanhaUNKNOWN Microcephaly Epidemic Research Group
Apr 2, 2020·The American Journal of Tropical Medicine and Hygiene·Jeanne BertolliGeorgina Peacock
Feb 23, 2019·Journal of Anatomy·Javier Gilbert-JaramilloKieran Clarke
Nov 21, 2018·Clinical Case Reports·Katia E F A CoelhoIvar V Brandi
Apr 2, 2020·The American Journal of Tropical Medicine and Hygiene·Roziah AliHan Lim Lee
Dec 12, 2018·PLoS Neglected Tropical Diseases·James A HaySteven Riley
Dec 28, 2019·Journal of Child Neurology·Laís Rodrigues GerzsonLavínia Schuler-Faccini
Nov 28, 2020·Maternal and Child Health Journal·Isabela Ornelas PereiraGeorgina Peacock
May 18, 2020·The Journal of Pediatrics·Romeo R GalangMartha L Ospina
Oct 30, 2020·Science Translational Medicine·Kevin M VannellaDaniel S Chertow
Nov 1, 2020·Pathogens·Sophie MasmejanDavid Baud
Mar 4, 2021·PLoS Neglected Tropical Diseases·Anna L FunkArnaud Fontanet
Jun 5, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ana Márcia Menezes de OliveiraPaulo Ricardo Saquete Martins-Filho

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