Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients

Schizophrenia Research
Caroline DubertretJean Adès

Abstract

The gene which codes for dopamine receptor D2 (DRD2) is considered as one of the most relevant candidate genes in schizophrenia. Previous genetic studies focusing on this gene gave conflicting results, potentially because of the differences in methodology (linkage versus association studies), and the different loci analyzed (the DRD2 gene having many polymorphisms). We used a progressive strategy with three different approaches (case/control, haplotype relative risk and transmission disequilibrium test) and investigated two genetic polymorphisms (TaqI B1/B2 and TaqI A1/A2, spanning the coding region of the DRD2 gene) in 50 patients with DSM-IV diagnoses of schizophrenia, in their 100 parents and in 50 healthy, matched controls. Firstly, we found a significant excess of the two alleles (B2 and A2) in the schizophrenic group compared to unaffected controls. Secondly, we found an excess of transmission from the parents to their affected children, using the haplotype relative risk design applied to the B2A2 haplotype. Finally, the transmission disequilibrium test showed evidence for linkage between B2A2 haplotype and schizophrenia. The significant excess of the B2A2 haplotype in schizophrenic patients is specifically observed in a ...Continue Reading

References

Oct 1, 1977·Archives of General Psychiatry·N C AndreasenG Winokur
Jan 1, 1992·Cytogenetics and Cell Genetics·V VielandJ Ott
Oct 2, 1991·JAMA : the Journal of the American Medical Association·D E ComingsB W Kovacs
Jul 1, 1991·Archives of General Psychiatry·H W MoisesJ L Kennedy
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D K GrandyA C Server
Jan 1, 1989·Genetic Epidemiology·J Ott
Jan 1, 1987·Journal of Psychiatric Research·L E DeLisiE S Gershon
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen, S Olsen
Jan 1, 1994·Psychiatric Genetics·C LaurentM Martinez
Aug 1, 1994·Psychiatry Research·J HallmayerD B Wildenauer
Feb 1, 1995·The American Journal of Psychiatry·P GorwoodJ Feingold
Nov 15, 1993·Biochemical and Biophysical Research Communications·M ItokawaM Toru
Dec 1, 1993·Human Molecular Genetics·D K GrandyO Civelli
Apr 23, 1994·Lancet·S ShaikhR Kerwin
May 21, 1994·Lancet·M M NöthenJ Körner
Mar 1, 1994·Psychiatry Research·D CampionP Gorwood
Jul 29, 1994·Biochemical and Biophysical Research Communications·M HattoriH Kazamatsuri
Aug 27, 1994·Lancet·J SobellS Sommer
Oct 15, 1993·American Journal of Medical Genetics·P AshersonP McGuffin
Aug 1, 1993·Journal of Medical Genetics·M J Owen, P McGuffin
Sep 1, 1996·The American Journal of Psychiatry·P GorwoodJ Feingold
Sep 13, 1996·Science·N Risch, K Merikangas
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·E JönssonG Sedvall
Apr 16, 1998·American Journal of Human Genetics·R S Spielman, W J Ewens
Aug 26, 1998·Neuropharmacology·K W Jones, S J Peroutka
Jun 1, 1955·Annals of Human Genetics·B WOOLF

❮ Previous
Next ❯

Citations

Jun 16, 2009·Neurotoxicity Research·Guillermo PonceJanet Hoenicka
Jun 19, 2004·Journal of Psychiatric Research·C DubertretP Gorwood
Jan 27, 2004·Schizophrenia Research·Caroline DubertretPhilip Gorwood
May 3, 2013·Pharmacogenetics and Genomics·Catherine J SpellicyDavid A Nielsen
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·C DubertretP Gorwood
Mar 21, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Igor BombinAna Patiño-Garcia
Feb 18, 2014·Genes, Brain, and Behavior·C J SpellicyD A Nielsen
Sep 16, 2006·Neuroscience Letters·Kari HänninenTerho Lehtimäki
Jul 31, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chen ZhangYiru Fang
Dec 17, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jun YaoBao-jie Wang
May 19, 2007·Schizophrenia Research·Andrew ShanerJim Mintz
Jan 17, 2012·The International Journal of Neuropsychopharmacology·Christoph VölterUlrich Ettinger
Sep 9, 2006·The International Journal of Neuropsychopharmacology·Clement C ZaiJames L Kennedy
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Undine E LangJurgen Gallinat
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Aug 19, 2006·Human Mutation·Ann Van Den BogaertChristine Van Broeckhoven
Sep 27, 2005·Neuroscience Letters·Ritushree KukretiSamir K Brahmachari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.