Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome

Pediatrics
Michael Klintschar, Christian Heimbold

Abstract

Abnormalities in the serotonergic as well as the noradrenergic neuronal systems are believed to contribute to sudden infant death syndrome (SIDS). The X-chromosomal monoamine oxidase A (MAOA) gene is of importance for both systems and up to now no systematic study on a functional polymorphism in this gene has been performed in a sufficiently large group. We investigated a functional MAOA promoter length polymorphism in 156 white SIDS cases and 260 gender- and age-matched control subjects by using capillary electrophoresis and fluorescence dye labeled primers. The pooled low-expressing alleles *2 and *3 were more frequent in the 99 male SIDS cases than in 161 male control subjects (44.4% vs 25.5%). However, there were no differences in female cases. The frequency of low expression alleles varied significantly with the age at death and were significantly more frequent in children who died between an age of 46 and 154 days than at an older age (54.9% vs 22.6%). Our results indicate a relationship between SIDS and the MAOA genotype in boys via influencing serotonergic and noradrenergic neurons in the brainstem. This locus is the first X-chromosomal locus associated with SIDS. Our results support the theory that abnormalities in the...Continue Reading

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Citations

Jul 6, 2013·International Journal of Legal Medicine·Katharina LäerMichael Klintschar
Nov 1, 2013·International Journal of Legal Medicine·Maximilian GroßMicaela Poetsch
Sep 4, 2012·Forensic Science, Medicine, and Pathology·Hannah C KinneyRoger W Byard
Jun 26, 2014·Pediatric Research·Nathan Salomonis
Mar 5, 2014·International Journal of Legal Medicine·Jacqueline StuderCordula Haas
Feb 9, 2013·The Journal of Pediatrics·Cornelius CourtsBurkhard Madea
Jul 1, 2014·Journal of Forensic Sciences·Jacqueline StuderCordula Haas
Jan 31, 2015·Forensic Science, Medicine, and Pathology·Carl E HuntBruce A Hyma
Aug 24, 2013·The Journal of Pediatrics·Michael KlintscharKatharina Läer
May 9, 2013·Psychological Science·Quetzal A ClassBrian M D'Onofrio
Dec 14, 2017·Italian Journal of Pediatrics·Raffaele PiumelliRenato Cutrera

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