Abstract
AIM.: To study the relationship between abnormal vaginal flora (AVF) in the first trimester as a risk factor for shortening cervix length (CL) at second and third trimester, and to assess the combination of these factors in predicting preterm delivery. METHODS.: 1026 unselected low risk women seen before 16 weeks of pregnancy underwent sampling of vaginal fluid for wet mount microscopy at a central laboratory blinded to clinical data. Disappearance of lactobacilli and bacterial vaginosis (BV) were scored according to standardized definitions. Specific cultures were performed for M hominis, U urealyticum, aerobic vaginitis (AV) and vaginal colonization with Candida. CL was measured by transvaginal ultrasound at 10-14, 20-24 and at 30-34 weeks, and gestational age at delivery was recorded. RESULTS.: Short cervix (CL below the lower quartile) at 10-14 weeks is related to a lower CL at 20-24 and 30-34 weeks of gestation (p=0.01, p=0.005 respectively). Short cervix at 20-24 weeks, but not at 10-14 weeks, was predictive for preterm birth. In patients with M. hominis and/or with severe AV at 10-14 weeks, the cervix appeared shorter at 20-24 and at 30-34 weeks than in other women. Increased risk for preterm birth in women with a shorte...Continue Reading
Citations
Mar 23, 2012·Archives of Gynecology and Obstetrics·Nemanja StojanovićSnežana Plešinac
Dec 15, 2010·Proteome Science·Geert ZegelsXaveer Wm Van Ostade
Jul 16, 2011·Trends in Endocrinology and Metabolism : TEM·Bryan A WhiteBrenda A Wilson
Apr 12, 2016·Metabolomics : Official Journal of the Metabolomic Society·Emmanuel AmabebeDilly O C Anumba
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·Ggg DondersD Rezeberga
Oct 8, 2013·American Journal of Obstetrics and Gynecology·Betsy FoxmanDawn Misra
Apr 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ji Ye KimJong-Hwa Kim
Oct 3, 2014·BMC Pregnancy and Childbirth·Matthew S PayneJohn P Newnham
Jul 21, 2016·The Journal of Obstetrics and Gynaecology Research·Qian LiangYing Duan
Nov 5, 2016·Anaerobe·Deborah B NelsonLaura Goetzl
Oct 16, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G S TansarliM E Falagas
Jul 6, 2014·Microbiome·Roberto RomeroJacques Ravel
Nov 24, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Cha HanFengxia Xue
Sep 13, 2019·PloS One·Emmanuel AmabebeDilly O C Anumba
Aug 29, 2020·The Libyan Journal of Medicine·Daiva BartkevicieneDiana Ramasauskaite
Sep 10, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Do Youn KwonCheong-Rae Roh