Association between ABO and Rh Blood Groups and Risk of Preeclampsia: A Case-Control Study from Iran

Open Access Macedonian Journal of Medical Sciences
Firoozeh Aghasadeghi, Mostafa Saadat

Abstract

Preeclampsia (PE) is a major cause of maternal and neonatal morbidity and mortality. There is a genetic component in the development of PE with estimated heritability around 0.47. Several studies have investigated the association between maternal ABO blood groups (OMIM 110300) and risk of PE, with contradictory results have emerged. Considering that there is no study in this filed from Iranian population, the present case-control study was carried out at Shiraz (south-west Iran). In this study 331 women; 121 pregnant with PE and 210 normotensive pregnant women were included. Using blood group O (for ABO blood groups) or Rh+ (for Rh blood groups) as a reference, odds ratios (ORs) and its 95% confidence intervals (95% CI) of PE risk were estimated from logistic regression analysis. Although the A (OR = 0.67, 95% CI = 0.39-1.17, P = 0.165), B (OR = 0.86, 95% CI = 0.48-1.53, P = 0.615) and AB (OR = 1.14, 95% CI = 0.37-3.45, P = 0.812) phenotypes showed lower risks compared with the O blood group, statistical analysis indicated that there was no significant association between ABO phenotypes and risk of PE. The frequency of Rh- phenotype was higher among PE patients compared with the control group. However, the association was not s...Continue Reading

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Citations

Jul 20, 2018·Journal of Circulating Biomarkers·Ranjeeta GaddeS R Sheela
Jul 9, 2021·Frontiers in Cardiovascular Medicine·Ting LiHongjuan Ding

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Software Mentioned

Statistical Package for Social Sciences ( SPSS

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