Association between abortion and breast cancer: an updated systematic review and meta-analysis based on prospective studies

Cancer Causes & Control : CCC
Jun GuoWengang Qin

Abstract

Although positive association between abortion and breast cancer was frequently reported from case-control studies, results from prospective studies were still unclear. This study aimed to evaluate this association based on prospective studies. PubMed, ISI Web of Knowledge and Embase were systematically searched for prospective studies on the association between abortion and breast cancer up to April 2014, supplemented by manual searches on the references. Two reviewers independently conducted the literature search, study selection, data extraction, and quality assessment of included studies. Random effects models were used to estimate the combined relative risks (RRs) and corresponding 95 % confidence intervals (95 % CIs). Fifteen prospective studies [14 focused on induced abortion (IA), and 12 focused on spontaneous abortion (SA)] were included in the final analysis. The combined RRs (95 % CIs) of breast cancer risk were 1.00 (0.94-1.05) [1.00 (0.92-1.08) for cumulative-incidence data and 1.00 (0.94-1.05) for incidence-rate data] for IA, and 1.02 (0.95-1.09) [1.06 (0.96-1.16) for cumulative-incidence data and 1.01 (0.92-1.09) for incidence-rate data] for SA, respectively. Non-significant associations of breast cancer with IA ...Continue Reading

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Citations

Aug 9, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Nicole S Carlson
Aug 16, 2016·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Laura E DodgeMichele R Hacker
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Mar 6, 2018·Medicine·Yongchun DengXiaoHua Zeng
Feb 6, 2019·International Journal of Cancer. Journal International Du Cancer·Mostafa DianatinasabReza Ghiasvand
Dec 5, 2017·International Journal of Breast Cancer·Mohammad Esmaeil AkbariMojtaba Amiri
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Oct 21, 2020·Hormone Molecular Biology and Clinical Investigation·Amir ShamshirianReza Alizadeh-Navaei
Aug 28, 2020·Pathology, Research and Practice·Rasoul AbdollahzadehJavad Tavakkoly-Bazzaz
May 6, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Serena C Houghton, Susan E Hankinson

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