Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer

Pharmacotherapy
Christoph R MeierHershel Jick

Abstract

To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer. Retrospective case-control study General practice offices. Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar time; 3706 women with breast cancer and 14,155 matched control subjects; and 635 women with colon cancer and 2434 matched control subjects. United Kingdom-based General Practice Research Database was searched for women aged 50-89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure. Regular acetaminophen exposure (> or = 30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7-1.0) but not ovarian (OR 1.0, 95% CI 0.6-1.5) or colon (OR 1.0, 95% Cl 0.7-1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3-0.9) but not ovarian or breast cancer. We found no evidence for a decreased ovarian cancer risk for women with regula...Continue Reading

References

Mar 6, 1991·Journal of the National Cancer Institute·L RosenbergS Shapiro
Sep 7, 1995·The New England Journal of Medicine·E GiovannucciF E Speizer
Oct 1, 1994·Cancer·J E MuscatE L Wynder
Mar 1, 1994·Epidemiology·D M Schreinemachers, R B Everson
Aug 15, 1993·Cancer·O SuhN J Petrelli
Jul 17, 1996·Journal of the National Cancer Institute·K M EganG A Colditz
Feb 22, 1997·Lancet·H JickC R Meier
Jan 24, 1998·Lancet·D W CramerE R Greenberg
Dec 16, 1998·Annals of Internal Medicine·T StürmerC H Hennekens
Jun 27, 1998·British Journal of Clinical Pharmacology·L A García Rodríguez, S Pérez Gutthann
Apr 23, 1999·Lancet·H Jick
Apr 23, 1999·Lancet·T Walley, A Mantgani
Feb 11, 2000·Archives of Internal Medicine·C R MeierH Jick
Nov 22, 2001·Preventive Medicine·A AkhmedkhanovR E Shore
Apr 10, 2004·Pharmacoepidemiology and Drug Safety·G D FriedmanM L Slattery
Nov 26, 2008·Pharmacoepidemiology and Drug Safety·M M Joffe

❮ Previous
Next ❯

Citations

Nov 4, 2008·Breast Cancer Research and Treatment·Ya-shuang ZhaoXia Li
Aug 31, 2011·Cancer Causes & Control : CCC·Jaclyn L F BoscoLynn Rosenberg
Dec 25, 2003·American Journal of Epidemiology·Luis Alberto García Rodríguez, Sonia Hernández-Díaz
Apr 4, 2009·American Journal of Epidemiology·Simone P PinheiroSusan E Hankinson
Oct 9, 2008·Journal of the National Cancer Institute·Bahi TakkoucheMahyar Etminan
Apr 5, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C BeckerC R Meier
Jan 16, 2008·International Journal of Clinical Practice·A Agrawal, I S Fentiman
Mar 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Gang XieBasil Rigas
Feb 10, 2006·Journal of Clinical Pathology·A JuutiC Haglund
Nov 28, 2007·Annual Review of Pathology·Thea D Tlsty, Lisa M Coussens
Feb 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna E PrizmentKristin E Anderson
Jun 6, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanMarc T Goodman
Jul 29, 2006·Drugs & Aging·Michael HoffmeisterHermann Brenner
May 23, 2014·Journal of the National Cancer Institute·Louise BaandrupSusanne K Kjaer
Feb 22, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Søren FriisJørgen H Olsen
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Karin E de VisserLisa M Coussens
May 15, 2007·Lancet·Enrico FlossmannUNKNOWN British Doctors Aspirin Trial and the UK-TIA Aspirin Trial
Jun 28, 2005·Pharmacotherapy·Lorenz M FischerChristoph R Meier
Jul 27, 2005·British Journal of Clinical Pharmacology·Stefanos BonovasNikolaos M Sitaras
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·James V LaceyCatherine Schairer
Dec 10, 2008·International Journal of Cancer. Journal International Du Cancer·Anna H WuMalcolm C Pike
Oct 24, 2007·Pharmacoepidemiology and Drug Safety·Sandra MangiapanePeter Schlattmann
Apr 17, 2008·Pharmacoepidemiology and Drug Safety·Yu-Xiao YangJames D Lewis
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Lisa GallicchioKathy J Helzlsouer
Jul 18, 2006·British Journal of Clinical Pharmacology·Stefanos BonovasNikolaos M Sitaras
Dec 18, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Louise BaandrupSusanne K Kjaer
Mar 3, 2012·Pharmacoepidemiology and Drug Safety·Rachel CharltonCorinne de Vries
Jun 1, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Henriette B AmmundsenSusanne K Kjaer
Apr 5, 2012·British Journal of Clinical Pharmacology·Xiaojian NiShui Wang
Nov 25, 2014·International Journal of Cancer. Journal International Du Cancer·Daphne ReinauChristoph R Meier
Dec 30, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BaandrupS Friis
Aug 21, 2010·The Breast : Official Journal of the European Society of Mastology·Varun AshokPaul D Terry
Jan 16, 2015·Breast Cancer Research and Treatment·María de PedroJavier Llorca
Sep 18, 2012·Cytokine & Growth Factor Reviews·Erin L WhitakerPenelope J Duerksen-Hughes
Aug 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xuehong ZhangSusan E Hankinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
James V LaceyCatherine Schairer
American Journal of Epidemiology
Charlotte G HannibalKara L Cushing-Haugen
© 2022 Meta ULC. All rights reserved