Association between (AC)n dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy: a meta-analysis

Journal of Molecular Endocrinology
Mingtong XuWeiqing Chen

Abstract

Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabetes mellitus case-control comparisons, which were based on our inclusion criterion and available in the literature. The meta-analysis demonstrated a large heterogeneity among the studies on the type 1 diabetic subjects and a significant association was observed between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy. The Z-2 allele appeared to be a genetic risk factor for susceptibility to diabetic nephropathy with a random effects odds ratio (OR) of 1.40 (95% confidence interval, CI (1.07, 1.84)). The Z+2 allele showed a protective effect on diabetic nephropathy with a random effects OR of 0.77 (95% CI (0.65, 0.91)). The meta-analysis, however, showed no association between the genetic polymorphism and diabetic nephropathy in type 2 diabetic subjects. Neither the risk Z-2 allele nor the protective Z+2 allele in type 1 diabetic subjects appeared to ha...Continue Reading

Citations

Dec 4, 2010·Diabetologia·A L MooyaartH J Baelde
Sep 24, 2008·Expert Opinion on Investigational Drugs·Monica CortinovisGiuseppe Remuzzi
May 1, 2012·American Journal of Medical Genetics. Part a·Sheri MitchellPinar Bayrak-Toydemir
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Jan 23, 2021·Diabetology International·Mohammad Bagher Hashemi-SotehAhmad Ahmadzadeh Amiri

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