Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis

Respiratory Research
Hui-Fang LiWei Tan

Abstract

Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between a disintegrin and metalloprotease 33 (ADAM33) polymorphisms and asthma risk, however, the results still remain inconclusive. The objective of the present study was to identify the effect of ADAM33 variants in asthma susceptibility. Eligible case-control studies published between January 2000 and June 2018 was searched and retrieved from online electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the effect. A total of 63 case-control studies were finally screened out, including 13,280 asthma patients and 13,340 controls. Eleven SNPs of ADAM33 gene were identified. Our results detected a significant association between ADAM33 T2, Q1, F + 1 and AA genotype of T + 1 polymorphisms and asthma risk in total population. Subgroup analysis by ethnicities showed that the alleles and genotypes of T2, Q1 and F + 1 polymorphisms were associated with asthma susceptibility among Asian populations, while V4 polymorphism was associated with ...Continue Reading

References

Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Sep 20, 2002·The New England Journal of Medicine·Steven D Shapiro, Caroline A Owen
Jul 30, 2003·Expert Opinion on Therapeutic Targets·Robert M PowellJohn W Holloway
Sep 6, 2003·American Journal of Respiratory and Critical Care Medicine·Denise L LindEsteban González Burchard
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Timothy D HowardDeborah A Meyers
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WernerM Wjst
Mar 5, 2004·Springer Seminars in Immunopathology·Julie A CakebreadStephen T Holgate
May 18, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H JongepierD S Postma
Jun 16, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J H LeeH D Shin
Jun 15, 2005·Pulmonary Pharmacology & Therapeutics·Stephen T HolgateJohn W Holloway
Nov 1, 2005·Immunology and Allergy Clinics of North America·Stephen T HolgateJohn W Holloway
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Ji-Yeon LeeChoon-Sik Park
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NoguchiT Arinami
Jun 15, 2006·European Journal of Human Genetics : EJHG·Mary-Anne KeddaPhilip J Thompson
Jun 27, 2006·Proceedings of the American Thoracic Society·Stephen T HolgateDonna E Davies
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T HirotaM Tamari
Aug 9, 2006·International Journal of Immunogenetics·P WangY Q Gong
Jan 2, 2007·The European Respiratory Journal·F D Martinez
Mar 7, 2007·The Journal of Allergy and Clinical Immunology·Susan C FoleyQutayba Hamid
Nov 27, 2009·International Archives of Allergy and Immunology·Candelaria I VergaraLuis Caraballo
May 19, 2010·Expert Review of Clinical Immunology·Claus Kroegel
Dec 24, 2010·Journal of Human Genetics·Shally AwasthiNuzhat Husain
Sep 21, 2011·Experimental and Molecular Pathology·Shuqiang QuLi Yao
Nov 1, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zhijun JieMeiling Jin
Feb 3, 2012·Molekuliarnaia biologiia·A S KarunasE K Khusnutdinova
May 16, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Y MiyakeM Arakawa
Jun 5, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marek GodavaRadek Vrtel
Dec 19, 2012·Journal of the Chinese Medical Association : JCMA·Chi-Huei ChiangUeng-Cheng Yang
Jan 22, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Blazenka Kljaic BukvicAdnan Custovic
Oct 22, 2013·Molecular Medicine Reports·Weilin XueZhao-Shan Zhou
Nov 30, 2013·Otolaryngologic Clinics of North America·Monica Oberoi PatadiaJacquelynne Corey
Jun 11, 2014·The Journal of Cell Biology·David J Erle, Dean Sheppard
Aug 26, 2014·Current Opinion in Allergy and Clinical Immunology·Victor E Ortega, Deborah A Meyers
Aug 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sangeetha VishweswaraiahNallur B Ramachandra
Oct 4, 2014·Molecular and Clinical Oncology·Nigela YilihamuUmesh Yadav
Oct 15, 2014·Genetic Testing and Molecular Biomarkers·Malek ZihlifRanda Naffa

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