Association between adipocytokines and insulin resistance in Indian hypertensive patients.

Indian Heart Journal
Sujata R Mahadik

Abstract

Although the relationship between obesity, hypertension (HT), and insulin resistance is well-recognised, the pathophysiological mechanism involved is relatively poorly understood. The present study aims in examining the relationship between adipocytokines and insulin resistance in Indian hypertensive patients to better understand the pathogenesis of HT. A total of 124 subjects including 41 controls, 41 obese, and 42 hypertensive patients were recruited in this cross-sectional study. Fasting adipocytokines (leptin, adiponectin, resistin) and highly sensitive C-reactive protein (hsCRP) levels were measured by enzyme-linked immunosorbent assay (ELISA). Insulin resistance (IR) index was calculated by the homeostasis model assessment (HOMA). The relation between these variables was studied by univariate and multiple logistic regression analysis. Among the hypertensive patients, obese hypertensive patients exhibited significantly increased HOMA-IR and altered adipocytokine profile compared to the non-obese control subjects. In a stepwise multiple linear regression analysis with IR as a dependant variable, the study shows leptin as a significant predictor in hypertensive patients. Multiple logistic regression analysis revealed that am...Continue Reading

References

Jul 8, 1999·Kidney & Blood Pressure Research·F KokotJ Cieplok
Sep 27, 2003·Clinical Endocrinology·Masato FuruhashiKazuaki Shimamoto
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideyuki MurakamiKazuaki Shimamoto
Aug 18, 2005·Experimental Physiology·William G Haynes
Jan 5, 2006·Nature Clinical Practice. Cardiovascular Medicine·Yuji Matsuzawa
Jan 10, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B Almeida-PitittoUNKNOWN Japanese-Brazilian Diabetes Study Group
Feb 27, 2007·Vascular Health and Risk Management·Paco E BravoEfrain Reisin
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya ImatohHiroshi Une
Mar 29, 2008·Metabolic Syndrome and Related Disorders·S R MahadikS D Mehtalia
May 20, 2008·Metabolic Syndrome and Related Disorders·Sujata R MahadikSuresh D Mehtalia
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shih-Hsien SungChen-Huan Chen

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Citations

Mar 15, 2018·Indian Journal of Endocrinology and Metabolism·Arundhati G DiwanAbhijit A Ghadge
Jan 17, 2019·Journal, Genetic Engineering & Biotechnology·Moushira ZakiYasser Elhosary

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