Abstract
The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A...Continue Reading
References
Aug 1, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, P Z Zimmet
Nov 3, 2001·Diabetologia·M BarbieriG Paolisso
Oct 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Yonas MullugetaYesehak Worku
Mar 4, 2014·Endocrinology and Metabolism Clinics of North America·Guido LastraJames R Sowers
Aug 12, 2014·BioMed Research International·Susana CoimbraMaria João Neuparth
Sep 19, 2015·Diabetes & Metabolism·L HeUNKNOWN DECODA study group
Aug 10, 2016·Clinical Science·Hudson ReddonDavid Meyre
Sep 9, 2016·Journal of Zhejiang University. Science. B·Shan-Shan WangSheng-Rong Shen
Jun 14, 2017·Life Sciences·Md Murad HossainTunku Kamarul
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Jul 30, 2018·Lipids in Health and Disease·Wen ZhouLinlin Li
Sep 10, 2018·Diabetes & Metabolism·M LiuS-C Yu
Oct 12, 2018·Biomolecules·Yisett GonzálezPatricia L Fernández
Oct 13, 2018·Nature Reviews. Endocrinology·Paul ZimmetLinong Ji
Dec 14, 2018·Lipids in Health and Disease·Samuel Antwi-BaffourMahmood Abdulai Seidu
May 28, 2019·Archives of Oral Biology·Xiaojing CaoHuanxin Meng
Nov 23, 2019·Scientific Reports·Jiwoo LeeWoo Je Lee