Association between adiponectin levels and endometrial carcinoma risk: evidence from a dose-response meta-analysis

BMJ Open
Tong LinWei-Min Kong

Abstract

Epidemiological studies evaluating the association between adiponectin levels and endometrial carcinoma risk have produced inconsistent results. Thus, a meta-analysis was conducted to assess the association between them. Pertinent studies were identified by a search of PubMed and Web of Knowledge through January of 2015. A random-effects model was used to combine the data for analysis. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. Twelve articles (5 prospective studies and 7 case-control studies) involving 1916 endometrial carcinoma cases were included in this meta-analysis. Pooled results suggested that highest adiponectin levels versus lowest levels were significantly associated with the risk of endometrial carcinoma (summary relative risk (RR)=0.525, 95% CI 0.388 to 0.712, I(2)=64.2%). The association was also found in postmenopausal women (summary RR=0.646, 95% CI 0.433 to 0.964), but not in premenopausal women. A linear dose-response relationship was found, with the risk of endometrial carcinoma decreasing by 3% for every 1 μg/mL increase in adiponectin levels (summary RR=0.97, 95% CI 0.96 to 0.98). No publication bias was found. Our analysis sug...Continue Reading

References

Jun 1, 1992·American Journal of Epidemiology·S Greenland, M P Longnecker
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Eleni PetridouDimitrios Trichopoulos
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Luigino Dal MasoCarlo La Vecchia
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Johan HoffstedtPeter Arner
May 26, 2004·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Aug 18, 2004·Trends in Genetics : TIG·Marcus R Munafò, Jonathan Flint
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Sep 15, 2005·JAMA : the Journal of the American Medical Association·Ahmedin JemalMichael Thun
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Anne E CustElio Riboli
Jan 5, 2007·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marc J GunterHoward D Strickler
Aug 3, 2010·Gynecologic Oncology·Naohiro AshizawaKenichi Tanaka
Nov 5, 2010·American Journal of Obstetrics and Gynecology·Pamela T SolimanKaren H Lu
Oct 8, 2011·Molecular Cancer Therapeutics·Hyun-Seuk MoonChristos S Mantzoros
Oct 4, 2012·Endocrine-related Cancer·Christine M FriedenreichLinda S Cook
May 23, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Patricia LuhnLouise A Brinton
Jul 31, 2013·Endocrine-related Cancer·Serpil ErdoganFatma Meric Yilmaz
Aug 22, 2013·International Journal of Clinical Oncology·Yukari OhbuchiKeiichi Isaka
Oct 30, 2013·Journal of Gynecologic Oncology·Yu MaBingjian Lu

❮ Previous
Next ❯

Citations

Nov 6, 2018·International Journal of Cancer. Journal International Du Cancer·Olivia RaglanMaria Kyrgiou
May 6, 2019·International Journal of Molecular Sciences·Luca GelsominoSebastiano Andò
Jun 20, 2019·International Journal of Molecular Sciences·Andrea TumminiaLucia Frittitta
Sep 12, 2020·Cancers·Iwona SidorkiewiczAdam Krętowski

❮ Previous
Next ❯

Methods Mentioned

BETA
blood
hormone replacement therapy

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.