Abstract
In the present pilot study, we evaluated the effect of maternal adiposity on the plasma concentration of adipocytokines in pregnant women and their newborns. Twenty patients with term gestations without labour were initially selected by pregestational BMI and then classified into two study groups (n 10 each), according to their median value of adiposity (total body fat). Concentrations of TNF-α, IL-1β, IL-6, leptin and adiponectin in plasma of maternal peripheral blood and fetal cord blood were measured and correlated to maternal adiposity. Maternal adiposity showed a significant negative correlation with fetal adiponectin (r - 0·587, P = 0·01) and IL-6 (r - 0·466, P = 0·05), a significant positive correlation with maternal leptin (r 0·527, P = 0·02) and no correlation with TNF-α or IL-1β. Adiponectin was higher in fetal plasma than in maternal plasma (P = 0·043), but significantly lower in newborns from women with high adiposity than in newborns from women with low adiposity (P = 0·040). Our results suggest that fetuses from obese women may be less able to control inflammation, due to lower circulating anti-inflammatory adipocytokines, which could limit their optimal development or even increase the risk of abortion or preterm...Continue Reading
References
Nov 1, 1992·American Journal of Obstetrics and Gynecology·J VillarJ T Repke
Feb 7, 1998·The Journal of Clinical Investigation·Z XingM K Achong
Oct 30, 2001·The Proceedings of the Nutrition Society·S W Coppack
Mar 19, 2002·Endocrinology·Haiyan XuGökhan S Hotamisligil
Sep 17, 2003·The Journal of Experimental Medicine·Taizo MatsukiYoichiro Iwakura
May 25, 2004·Pediatric Research·Rose M ViscardiJeffrey D Hasday
Oct 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Kirsten Riis AndreasenAnne Louise Schantz
Mar 30, 2005·Obstetrical & Gynecological Survey·Lanniece F Hall, A George Neubert
Mar 9, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Noriyuki Ouchi, Kenneth Walsh
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naomi M ScottVicki L Clifton
Feb 7, 2009·Obesity·Subhabrata BasuSylvie Hauguel-de Mouzon
Feb 12, 2009·Reproductive Sciences·John R ChallisFelice Petraglia
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grant N ScottLaura Mandik-Nayak
Jun 10, 2009·Cytokine·Juliette C MadanOlaf Dammann
Jul 17, 2009·Metabolism: Clinical and Experimental·Umesh MasharaniJack F Youngren
Aug 12, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Minghua ChenOlaf Dammann
Nov 13, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·M SchmatzJ Davis
Citations
Mar 19, 2013·Obesity·Camilla M FriisTore Henriksen
May 15, 2015·Placenta·P PanthamT L Powell
Jul 15, 2015·Adipocyte·Marlies K OziasSusan E Carlson
Mar 14, 2014·Diabetes Care·Angela C EstampadorPaul W Franks
Oct 17, 2016·Paediatric Respiratory Reviews·Franca Rusconi, Maja Popovic
Oct 21, 2014·BoneKEy Reports·Krista CasazzaDavid A Fields
Jun 3, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Kelley L BaumgartelYvette P Conley
Aug 8, 2017·Nutrients·Flaminia BardanzelluAlessandra Reali
Sep 5, 2020·PloS One·Maria Hernandez-TrejoNorma Estela Herrera-González
Apr 19, 2017·BioFactors·Mahmi FujimoriAdenilda Cristina Honório-França
Dec 12, 2020·Molecular Genetics & Genomic Medicine·Karla MacDonald-Ramos, Rodrigo Vega-Sánchez
Dec 9, 2017·The Journal of Pediatrics·Brianna F MooreDana Dabelea
Aug 8, 2021·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina