Association Between Adjuvant Chemotherapy Duration and Survival Among Patients With Stage II and III Colon Cancer: A Systematic Review and Meta-analysis

JAMA Network Open
Devon J BoyneDarren R Brenner

Abstract

The results from the recent International Duration Evaluation of Adjuvant Therapy (IDEA) collaboration have led some clinicians to adopt shorter durations of adjuvant chemotherapy for patients with stage III colon cancer. The extent to which these findings are supported by other data is unknown. To conduct a systematic review and meta-analysis of randomized and observational studies investigating the association between the duration of adjuvant chemotherapy and survival among individuals diagnosed as having stage II and III colon cancer (PROSPERO protocol CRD42018108711]). Abstracts published in English between 2003 and 2018 within the MEDLINE, Embase, CENTRAL, and CINAHL databases were reviewed by 2 authors. Also searched were conference proceedings and the indexes of high-impact oncology journals. Studies were excluded if they did not present original data; focused on animal populations, on cancers in sites other than the colon, or on patients with stage 0, I, or IV disease; did not examine a 5-flourouracil-based monotherapy or combination therapy; or did not evaluate the association between treatment duration and survival. The search identified 2341 articles, from which 2 randomized trials and 20 observational studies were i...Continue Reading

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Citations

Nov 14, 2020·Journal of Cancer Survivorship : Research and Practice·Cynthia S BonhofFloortje Mols
Oct 26, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F PetrelliUNKNOWN TOSCA Investigators
May 22, 2021·Seminars in Cancer Biology·Mohd SaeedFarrukh Aqil
Sep 15, 2021·International Journal of Cancer. Journal International Du Cancer·Jemma M BoyleAjay Aggarwal

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Software Mentioned

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