Association between AIDS disease progression rates and the Fok-I polymorphism of the VDR gene in a cohort of HIV-1 seropositive patients

The Journal of Steroid Biochemistry and Molecular Biology
Gema NietoJ Fibla

Abstract

In addition to its role in mineral metabolism, 1,25-dihydroxivitamin D3 (1,25(OH)2D3) also has immunomodulatory effects. Vitamin D receptor (VDR) mediates genomic actions of 1,25(OH)2D3, by acting as a transcription factor that modulates the expression of several 1,25(OH)2D3 response genes. Variations at the VDR locus have been associated with susceptibility and progression to several immune diseases. We investigated the association between rates of progression to acquired immunodeficiency syndrome (AIDS) and the Fok-I polymorphism, which is located at the initiation codon of the VDR gene. The study was performed with a cohort of 185 patients infected with human immunodeficiency virus type 1 (HIV-1): all belonged to the intravenous drug abuse risk group. Progression to AIDS was according to the Centers for Disease Control 1993 criterion (CDC-1993). In addition, a first drop in CD4 cell count to below 200 microL(-1) was considered as outcome. Patients who reached outcomes during follow-up were considered progressors. Non-progressors were those patients remaining outcome-free after a minimum follow-up of 8 years. Heterozygous at the Fok-I polymorphism were over-represented in the group of patients that progressed to AIDS CDC-1993...Continue Reading

References

Dec 1, 1995·Nature Medicine·T CarlingH Melhus
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J M Lemire
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jan 15, 1997·Journal of the National Cancer Institute·S A InglesG A Coetzee
Dec 8, 1998·The Journal of Infectious Diseases·S RoyA V Hill
Jun 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·B K PattersonA Landay
Jul 25, 2000·Thyroid : Official Journal of the American Thyroid Association·Y BanT Katagiri
Sep 15, 2000·Human Genetics·L Correa-CerroW Vogel
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arndt VogelMichael P Manns

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Citations

Sep 21, 2007·European Journal of Clinical Pharmacology·Jana FlüggeIvar Roots
Sep 1, 2011·AIDS Research and Human Retroviruses·Rustin D CrutchleyKevin W Garey
Jun 26, 2014·Current HIV/AIDS Reports·Allison Ross Eckard, Grace A McComsey
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Steen B Haugaard
Sep 29, 2011·Tuberculosis·S RaghavanP Selvaraj
Sep 25, 2010·Placenta·J S ShinD M Nelson
Aug 8, 2014·Scientifica·Anna K CoussensRobert J Wilkinson
Jan 20, 2012·Dermato-endocrinology·Dima A YoussefAlan N Peiris
Jul 13, 2006·FEMS Immunology and Medical Microbiology·Umeshc ChaturvediRicha Shrivastava
Feb 3, 2007·European Journal of Immunology·Evelyne van EttenChantal Mathieu
Feb 7, 2012·Critical Reviews in Microbiology·Ai Leng KhooAndré van der Ven
Jun 7, 2019·Journal of Cellular Biochemistry·Hongbing RuiXiaoqiang Zheng
Mar 8, 2019·Journal of Clinical Medicine·María A Jiménez-SousaSalvador Resino

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