Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients

Genes, Brain, and Behavior
L A V MagnoMarco Aurélio Romano-Silva

Abstract

We tested the hypothesis that the presence of AKT1 and AKTIP polymorphisms, target genes that encode key proteins in the signaling of dopaminergic and serotonergic systems, is associated with suicidal behavior in bipolar patients. The subjects were 273 patients diagnosed with bipolar disorder I or II (age = 41.4 +/- 12.9). TaqMan single-nucleotide polymorphism genotyping assays (AKT1: rs2494731, rs3803304, rs3730358, rs10149779, rs2494746, rs1130214 and rs249878; AKTIP: rs9302648 and rs7189819) were used. We found that the AKT1 marker showed an association with suicide attempts (rs1130214, P < 0.05) and attempted violent attacks (rs2494746, P < 0.05). One out of the seven tested markers of AKT1 attained significant genotype association with violent attempt (rs2494731; P < 0.05). A significant association was detected in the AKT1 haplotype test. We did not observe an association between suicidal behavior and AKTIP variants and also did not find an interaction between AKTIP and AKT1 polymorphisms. In addition, we found that demographic and clinical data are associated with lifetime history of suicide attempts. Our data suggest that demographic and clinical characteristics and AKT1 single markers and haplotypes, but not AKTIP poly...Continue Reading

References

Oct 1, 1976·Archives of General Psychiatry·M AsbergP Thorén
Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Feb 2, 1999·The British Journal of Psychiatry : the Journal of Mental Science·E T Isometsä, J K Lönnqvist
Jul 13, 1999·Archives of General Psychiatry·R C KesslerE E Walters
Nov 15, 2000·American Journal of Human Genetics·A M DunningB A Ponder
Dec 1, 2000·The American Journal of Psychiatry·J B PotashJ R DePaulo
May 1, 2001·The American Journal of Psychiatry·M F GrunebaumJ J Mann
Feb 19, 2002·Annals of Internal Medicine·J John Mann
Jun 27, 2002·Schizophrenia Research·Humberto CorrêaJean-Paul Macher
Dec 24, 2003·Journal of Psychiatric Research·Ming T TsuangStephen V Faraone
Jan 30, 2004·Molecular and Cellular Biology·Ingrid Remy, Stephen W Michnick
Mar 10, 2004·Bipolar Disorders·Christer EngströmPer-Olof Nylander
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 5, 2004·Expert Review of Molecular Diagnostics·Jason H Moore
Nov 29, 2005·Journal of Affective Disorders·Leo SherBarbara H Stanley
Feb 7, 2006·Biological Psychiatry·Haim Einat, Husseini K Manji
Feb 8, 2006·Molecular Psychiatry·B BondyP Zill
Oct 18, 2006·Bipolar Disorders·Michael F GrunebaumMaria A Oquendo
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Martin BeaulieuMarc G Caron
Mar 14, 2007·Trends in Pharmacological Sciences·Jean-Martin BeaulieuMarc G Caron
Mar 23, 2007·Genes, Brain, and Behavior·D WassermanJ Wasserman
Jun 21, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·F S NevesH Correa
Oct 24, 2007·Cellular and Molecular Life Sciences : CMLS·E M Sale, G J Sale
Jan 15, 2008·Cell·Jean-Martin BeaulieuMarc G Caron
May 6, 2008·PLoS Genetics·William G HillPeter M Visscher
May 20, 2008·Journal of Affective Disorders·Leandro F Malloy-DinizHumberto Corrêa
May 27, 2008·Psychopharmacology·Renan P SouzaJames L Kennedy
Aug 1, 2008·Psychological Medicine·J G FiedorowiczW H Coryell
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Maurizio PompiliEleonora De Pisa
Nov 26, 2008·The Journal of Clinical Psychiatry·Fernando Silva NevesHumberto Corrêa

❮ Previous
Next ❯

Citations

Sep 22, 2012·Current Psychiatry Reports·Ute LewitzkaAnne C Duffy
May 31, 2011·Journal of Affective Disorders·Luiz Alexandre V MagnoMarco A Romano-Silva
Oct 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen TsaiYing-Jay Liou
Oct 31, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Innokentiy S LosenkovSvetlana A Ivanova
Sep 12, 2013·International Journal of Geriatric Psychiatry·Patricia Araújo PereiraMarco Aurélio Romano-Silva
Sep 28, 2014·Journal of Affective Disorders·Lucas da Silva CostaModesto Leite Rolim Neto
Sep 3, 2014·Molecular Psychiatry·M SokolowskiD Wasserman
Jun 13, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jeverson MoreiraCynthia Marie-Claire
Jan 20, 2020·Current Psychiatry Reports·Jacob N Miller, Donald W Black
May 17, 2021·Neurochemistry International·Aarti Sharma, Sidharth Mehan

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Psychiatry Research
William Coryell, Michael Schlesser
European Psychiatry : the Journal of the Association of European Psychiatrists
P McGuffinA Farmer
Journal of Affective Disorders
A Roy, N L Segal
© 2021 Meta ULC. All rights reserved