Association between alcohol consumption and serum paraoxonase and arylesterase activities: a cross-sectional study within the Bavarian population

The British Journal of Nutrition
Carolina SchwedhelmJakob Linseisen

Abstract

High alcohol consumption is an important risk factor for chronic disease and liver degeneration. Paraoxonase (PON1) and arylesterase (AE) are functions of the enzyme paraoxonase, which is synthesised by the liver. Paraoxonase circulates in plasma bound to HDL and hydrolyses lipid peroxides, protecting lipoproteins against oxidative modification. It has been shown that excessive alcohol consumption leads to a reduction of serum PON1 and AE activities; however, studies investigating the association with low and moderate alcohol consumption are scarce. We investigated the cross-sectional association between alcohol consumption and serum activities of PON1 and AE using data from the population-based Bavarian Food Consumption Survey II survey. PON1 and AE activities were quantified in serum samples of 566 male and female study participants (aged 18-80 years), and dietary intake including alcohol consumption was estimated from three 24-h dietary recalls. The association between alcohol consumption and PON1 and AE activities was analysed using linear regression, adjusted for age, sex and socio-economic status. There was no strong association between alcohol consumption and enzymatic activities of PON1 and AE in the Bavarian population...Continue Reading

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Citations

Oct 31, 2018·The American Journal of Clinical Nutrition·Eke G GruppenRobin P F Dullaart
Dec 29, 2018·Current Neuropharmacology·Estefania Gastaldello MoreiraMichael Maes

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