Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease

The American Journal of the Medical Sciences
Binxia ChangZhengsheng Zou

Abstract

Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD), though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases. The aim of this study is to determine the association between aldehyde dehydrogenase 2 (rs671) glu504lys polymorphism and ALD. ALDH2 genotyping was performed in 535 healthy controls and 281 patients with ALD. The prevalence of the common form of the single nucleotide polymorphism rs671, 504glu (glu/glu) was significantly higher in patients with ALD (95.4%) compared to that of controls (73.7%, P < 0.0001). Among controls, 23.7% had the heterozygous (glu/lys) genotype compared to 4.6% in those with ALD (odds ratio [OR] = 0.16, 95% CI: 0.09-0.28). The allele frequency for 504lys allele in patients with ALD was 2.3%, compared to 14.5% in healthy controls (OR = 0.13, 95% CI: 0.07-0.24). Patients with ALDH2 504lys varian...Continue Reading

References

Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·E N Petersen
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A YoshidaM Ikawa
Jun 1, 1994·Alcoholism, Clinical and Experimental Research·H R ThomassonS J Yin
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·J B Whitfield, N G Martin
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BorràsX Parés
Jun 17, 2005·Journal of Studies on Alcohol·Travis A R CookTamara L Wall
Oct 21, 2010·Seminars in Liver Disease·Margaret S SozioDavid Crabb
Feb 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyo-Jung KwonBin Gao
Apr 16, 2015·Alcoholism, Clinical and Experimental Research·John B WhitfieldUNKNOWN GenomALC Consortium
Jun 26, 2015·Alcoholism, Clinical and Experimental Research·Gina GoughSuthat Liangpunsakul
Mar 1, 2016·Gastroenterology·Suthat LiangpunsakulGeoffrey W McCaughan
Mar 24, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Wanzhu TuSuthat Liangpunsakul

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Citations

Feb 20, 2021·Journal of Clinical and Translational Hepatology·Qiaoling WangZhengsheng Zou
Nov 3, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiao-Yu SongTakashi Ikejima

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