Association between allopurinol use and hip fracture in older patients

Bone
Ujani BasuMiles D Witham

Abstract

Allopurinol reduces oxidative stress and interacts with purinergic signalling systems important in bone metabolism and muscle function. We assessed whether allopurinol use was associated with a reduced incidence of hip fracture in older people. Analysis of prospective, routinely-collected health and social care data on patients undergoing health and social work assessment in a single geographical area over a 12year period. Exposure to allopurinol was derived from linked community prescribing data, and hospitalisation for hip fracture and comorbid disease was derived from linked hospitalisation data. Fine and Gray modelling was used to model time to hip fracture accounting for the competing risk of death, incorporating previous use of allopurinol, cumulative exposure to allopurinol as a time dependent variable, and covariate adjustments. 17,308 patients were alive at the time of first social work assessment without previous hip fracture; the mean age was 73years. 10,171 (59%) were female, and 1155 (8%) had at least one exposure to allopurinol. 618 (3.6%) sustained a hip fracture, and 4226 (24%) died during a mean follow-up of 7.2years. In fully-adjusted analyses, each year of allopurinol exposure conferred a hazard ratio of 1.01...Continue Reading

References

Aug 11, 2001·Free Radical Biology & Medicine·N ModyL L Demer
Jul 13, 2005·Age and Ageing·Adriaan M KamperUNKNOWN PROSPER Study Group
Jan 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P N SambrookJ M Simpson
May 2, 2008·European Journal of Pharmacology·Amos A FatokunRobert A Smith
Mar 2, 2010·Current Opinion in Pharmacology·Isabel R OrrissTimothy R Arnett
May 19, 2010·International Journal of Molecular Sciences·Si-Jin Meng, Long-Jiang Yu
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Iraj NabipourMarkus J Seibel
Aug 3, 2011·Archives of Physical Medicine and Rehabilitation·Miles D WithamMarion E McMurdo
Nov 5, 2011·Purinergic Signalling·A BornøP Thaning
May 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnG S Kim
Jul 5, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Almeida, Charles A O'Brien
Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
Nov 26, 2013·Metabolism: Clinical and Experimental·Wei ChenDiana Jalal
Dec 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nancy E LaneUNKNOWN Osteoporotic Fractures in Men Study Group
Mar 22, 2014·Informatics for Health & Social Care·Miles D WithamMark McGilchrist
Mar 29, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B-J KimJ-M Koh
Dec 11, 2014·Metabolism: Clinical and Experimental·Tapan MehtaDiana Jalal

❮ Previous
Next ❯

Citations

Mar 13, 2016·Experimental Cell Research·Isabel R OrrissMiles D Witham
Aug 20, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Seoyoung C KimDaniel H Solomon
Aug 29, 2019·Journal of Orthopaedic Surgery and Research·Fanxiao LiuFei Xiong
Oct 12, 2017·Calcified Tissue International·Nicola DalbethJillian Cornish
Jul 1, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P BuzkovaK J Mukamal
Sep 8, 2019·Nutrients·Kun-Mo LinKuo-Cheng Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.