Association between aminolevulinate dehydrase genotypes and blood lead levels in children from a lead-contaminated area in Antofagasta, Chile

Archives of Environmental Contamination and Toxicology
F Pérez-BravoA Fontanellas

Abstract

Childhood environmental lead exposure in the city of Antofagasta, Chile, was generated by the accumulation of recently removed lead stores derived from mining activities for a long period of time. Susceptibility to harmful lead effects may be associated with polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) because of the differential binding of lead to the codified proteins. We assessed the associations and possible interactions among the following variables: blood lead levels, ALAD genotypes, and distance to the source of lead contamination in Chilean children exposed to lead contamination in Antofagasta, Chile. Ninety-three children were recruited from schools located near a lead- contaminated area. Lead blood levels were measured by atomic absorption spectrophotometry. ALAD genotypes were determined by polymerase chain reaction and restriction fragment-length polymorphism analysis. The frequency of the ALAD-2 allele was estimated at 0.054. Children with the ALAD-2 genotype had higher blood lead levels than noncarriers (p = 0.06). As expected, blood lead levels were inversely correlated with the distance from lead stores. Interestingly, ALAD-2 carriers were more frequent within the area defined by a distance of 2...Continue Reading

Citations

Dec 13, 2005·Archives of Toxicology·Marcelo F MontenegroJose E Tanus-Santos
Feb 3, 2012·Biochemical Genetics·Ana O MoreiraJoão Paulo Teixeira
Oct 30, 2007·Journal of Toxicology and Environmental Health. Part a·Yang ZhaoFeng Chen
Oct 26, 2013·Journal of Toxicology and Environmental Health. Part a·Ariane LeroyerCatherine Nisse
Sep 22, 2009·Toxicology Letters·Junko FujiharaHaruo Takeshita
May 31, 2016·International Journal of Environmental Research and Public Health·Feng ZhangBaoli Zhu
Dec 8, 2017·Critical Reviews in Clinical Laboratory Sciences·Prasenjit MitraPraveen Sharma
Mar 21, 2007·Environmental Health Perspectives·Franco ScinicarielloBruce A Fowler
Jan 14, 2010·Ciência & saúde coletiva·Rita de Cássia Oliveira da Costa MattosMaria de Fátima Malizia Alves

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