Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits

Translational Psychiatry
Johanna M HoppeTomas Furmark

Abstract

Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress and anxiety-related behavior. Alterations in the SP-NK1 system have also been observed in human anxiety disorders, yet little is known about the relation between this system and individual differences in personality traits associated with anxiety propensity and approach-avoidance behavior, including trait anxiety, neuroticism, and extraversion. Exploring this relation could provide important insights into the neurobiological underpinnings of human anxiety and the etiology of anxiety disorders, as anxious traits are associated with increased susceptibility to develop psychopathological conditions. Here we examined the relationship between central NK1 receptor availability and self-rated measures of trait anxiety, neuroticism, and extraversion. The amygdala was chosen as the primary region of interest since this structure has been suggested to mediate the effect of the SP-NK1 system on anxiety. Anxious traits and NK1 receptor availability, determined with positron emission tomography and the radiotracer [11C]GR205171, were measured in 17 healthy individuals. Voxel-wise analyses showed a significant positive correlation betw...Continue Reading

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Citations

May 15, 2019·Current Opinion in Neurology·Sabine Hellwig, Katharina Domschke
Aug 31, 2019·Pharmacology & Therapeutics·Simone B Sartori, Nicolas Singewald
Jan 23, 2021·CNS & Neurological Disorders Drug Targets·Viktor S KokhanGjumrakch Aliev
Jan 8, 2022·Medicinal Research Reviews·Kristina RepovaFedor Simko

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Methods Mentioned

BETA
PCA
genotyping

Software Mentioned

Statistical Parametric Mapping 8 SPM8
PVElab
SPSS Statistics
STAI

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