Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders.

Neuropsychologia
Natalia M KleinhansElizabeth Aylward

Abstract

Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age, IQ, and gender matched controls. In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation. During fMRI scanning, study participants were instructed to match facial expressions depicting fear or anger. The control condition was a comparable shape-matching task. The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching. Further, within the ASD group, greater social anxiety was associated with increased activation in right amygdala and left middle temporal gyrus, and decreased activation in the fusiform face area. These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD.

References

Apr 4, 1969·Science·P EkmanW V Friesen
Aug 1, 1969·Journal of Consulting and Clinical Psychology·D Watson, R Friend
Feb 1, 1995·The American Journal of Psychiatry·M ZilboviciusG Lelord
Apr 27, 2000·Neuroscience and Biobehavioral Reviews·S Baron-CohenS C Williams
Feb 13, 2002·Neurology·Manuel F CasanovaEmil Roy
Sep 30, 2003·The American Journal of Psychiatry·Ralph-Axel MüllerEric Courchesne
Oct 17, 2003·Brain Research. Cognitive Brain Research·Matthew K Belmonte, Deborah A Yurgelun-Todd
Jun 10, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Judith PiggotAllan L Reiss
Jun 10, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·A Ting WangSusan Y Bookheimer
Jun 29, 2004·NeuroImage·Nouchine HadjikhaniHelen Tager-Flusberg
Aug 21, 2004·Brain : a Journal of Neurology·Karen PierceEric Courchesne
Nov 17, 2004·Annals of Neurology·Diana L VargasCarlos A Pardo
Jan 18, 2005·NeuroImage·Hideya KoshinoMarcel Adam Just
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert T Schultz
Mar 8, 2005·Nature Neuroscience·Kim M DaltonRichard J Davidson
Nov 9, 2005·Nature Reviews. Neuroscience·Mark H Johnson
Feb 1, 2006·Human Brain Mapping·Adriana AragriFrancesco Di Salle
Nov 30, 2006·Human Brain Mapping·Nouchine HadjikhaniHelen Tager-Flusberg
Nov 3, 2007·Journal of Autism and Developmental Disorders·Lindsey SterlingJessica Greenson
Jan 5, 2008·Social Cognitive and Affective Neuroscience·Kevin A PelphreyKevin S Labar
Feb 1, 2008·Brain : a Journal of Neurology·Natalia M KleinhansElizabeth Aylward
Jul 16, 2008·Biological Psychiatry·Karen Pierce, Elizabeth Redcay
Jul 18, 2008·Social Neuroscience·Chris AshwinSimon Baron-Cohen
Jul 23, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Emily SimonoffGillian Baird
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·Susan Y BookheimerMirella Dapretto
Nov 14, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shuken BokuTsukasa Koyama
Feb 19, 2009·Clinical Psychology Review·Susan W WhiteLawrence Scahill
Feb 19, 2009·The American Journal of Psychiatry·Natalia M KleinhansElizabeth Aylward
Mar 4, 2009·Archives of General Psychiatry·Katja BeesdoDaniel S Pine
Apr 11, 2009·Autism Research : Official Journal of the International Society for Autism Research·Carla A MazefskyJanet E Lainhart
Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
Feb 27, 2010·Journal of Psychiatry & Neuroscience : JPN·Christopher S MonkCatherine Lord

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Citations

Apr 25, 2012·Child Psychiatry and Human Development·Nina WongValerie Sims
Jun 30, 2011·Journal of Autism and Developmental Disorders·Susan W WhiteThomas H Ollendick
Jun 28, 2012·Journal of Autism and Developmental Disorders·Susan W WhiteLawrence Scahill
Feb 2, 2013·Journal of Autism and Developmental Disorders·Hirokazu DoiKazuyuki Shinohara
May 3, 2013·Journal of Autism and Developmental Disorders·Antoinette SabatinoGabriel S Dichter
Jan 8, 2011·Neurotoxicity Research·Aysenil BelgerFranc C L Donkers
Jan 16, 2014·Translational Psychiatry·N HadjikhaniC Gillberg
Oct 26, 2012·Journal of Abnormal Child Psychology·Danielle BonsJan K Buitelaaar
Jul 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leanna M HernandezMirella Dapretto
Sep 13, 2016·Infancy : the Official Journal of the International Society on Infant Studies·Jennifer B WagnerCharles A Nelson
Jan 24, 2016·Journal of Psychiatric Research·Soo-Hee ChoiJae-Jin Kim
Feb 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martin H Teicher, Jacqueline A Samson
Oct 4, 2014·Neuroscience and Biobehavioral Reviews·E Quattrocki, Karl Friston
Jun 27, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Carla A MazefskySusan W White
Sep 6, 2015·Journal of Autism and Developmental Disorders·Natalia M KleinhansElizabeth Aylward
Dec 17, 2015·Autism Research : Official Journal of the International Society for Autism Research·Natalia M KleinhansAnnette Estes
May 29, 2012·Child Development Perspectives·Carla A MazefskyRonald E Dahl
Apr 11, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Catherine Lord, Rebecca M Jones
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jordan W Smoller
Feb 18, 2016·The Quarterly Journal of Experimental Psychology : QJEP·Sara Jane WebbSusan Faja
Feb 13, 2016·Social Cognitive and Affective Neuroscience·John D HerringtonRobert T Schultz
Jan 13, 2015·Journal of Autism and Developmental Disorders·Susan W WhiteRobin K Panneton
Nov 23, 2015·Journal of Autism and Developmental Disorders·Noah J SassonAmy E Pinkham
Aug 6, 2015·Journal of Autism and Developmental Disorders·Brenna B Maddox, Susan W White
Jun 14, 2015·Journal of Autism and Developmental Disorders·Tamara MayNicole J Rinehart
Apr 16, 2014·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Susan W WhiteLawrence Scahill
Jul 28, 2015·Journal of Neurodevelopmental Disorders·Caitlin M HudacRaphael A Bernier
Dec 7, 2014·Journal of Autism and Developmental Disorders·Jane E JosephRamesh S Bhatt
Jun 22, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Susan W WhiteThomas H Ollendick
Apr 2, 2015·Neuropsychologia·Jason S Nomi, Lucina Q Uddin
Nov 12, 2013·Research in Developmental Disabilities·Hannah E KirkKim M Cornish
Jul 16, 2014·Biological Psychology·Heather J NuskeCheryl Dissanayake
Jan 21, 2015·Current Opinion in Psychiatry·Roma A Vasa, Micah O Mazurek
Sep 16, 2014·Social Neuroscience·Amandine Lassalle, Roxane J Itier
Jun 11, 2016·Research in Developmental Disabilities·Amanda K Ludlow, Arnold J Wilkins
Jun 22, 2016·Journal of Autism and Developmental Disorders·Nicole N CapriolaSusan W White
Sep 1, 2016·Molecular Autism·Heather J NuskeCheryl Dissanayake
Feb 11, 2015·Social Neuroscience·Anat PerrySimone G Shamay-Tsoory

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