Association between an agouti-related protein gene polymorphism and anorexia nervosa

Molecular Psychiatry
T VinkR A Adan

Abstract

Anorexia nervosa (AN) is a life threatening disorder affecting mostly adolescent women. It is a dramatic psychiatric syndrome accompanied by severe weight loss, hyperactivity and neuroendocrine changes (reviewed in Refs 1 and 2). Several studies have shown a strong genetic component in AN (reviewed in Ref 3). Recent advances in unraveling the mechanisms of weight control point to a crucial role of the melanocortin-4 receptor (MC4-r) system in regulating body weight. The orexigenic neuropeptide agouti-related protein (AGRP), a MC4-r antagonist, plays a crucial role in maintaining body weight, by inducing food intake. The sequence of the coding region of the human AGRP gene (AGRP) was determined and the AGRP of 100 patients with AN was screened for variations. Three single nucleotide polymorphisms (SNPs) were identified and screened in a further 45 patients and 244 controls. Two alleles were in complete linkage disequilibrium and were significantly enriched in anorectic patients (11%; P = 0.015) compared to controls (4.5%). These data indicate that variations of AGRP are associated with susceptibility for AN. This is possibly caused by defective suppression of the MC4-r by the variant AGRP, leading to a decreased feeding signal, ...Continue Reading

References

Dec 16, 1995·Lancet·J HebebrandW Herzog
Jan 1, 1995·Human Genetics·J Hebebrand, H Remschmidt
Jan 1, 1996·Nature Medicine·C Bergh, P Södersten
Jun 23, 1998·Lancet·S SorbiC M Rotella
Apr 30, 1999·Journal of Psychiatric Research·R K StøvingC Hagen
Jan 7, 2000·Neuroscience Letters·B NacmiasS Sorbi
Jul 21, 2000·The Journal of Clinical Investigation·C VaisseP Froguel

❮ Previous
Next ❯

Citations

Apr 27, 2005·The International Journal of Eating Disorders·Kelly L Klump, Kyle L Gobrogge
May 13, 2008·Cellular and Molecular Life Sciences : CMLS·O Ilnytska, G Argyropoulos
Dec 25, 2009·European Child & Adolescent Psychiatry·Susann ScheragAnke Hinney
Nov 19, 2003·European Journal of Pharmacology·Martien J H KasRoger A H Adan
Jun 18, 2005·Peptides·Adrian M StützGeorge Argyropoulos
Jun 27, 2001·Journal of the American Dietetic Association·J McCaffree
Mar 14, 2002·Brain Research. Brain Research Reviews·Helgi B Schiöth, Hajime Watanobe
Jun 26, 2003·Trends in Pharmacological Sciences·Roger A H Adan, Martien J H Kas
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R A Adan, T Vink
Mar 24, 2011·Psychological Medicine·J V MerleS Ehrlich
Mar 29, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C T M van RossumJ C Seidell
Oct 31, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carrie Haskell-LuevanoZhimin Xiang
Mar 19, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·A B Loucks
Sep 14, 2001·Biochemical and Biophysical Research Communications·D K MayfieldG Argyropoulos
Mar 30, 2013·Annual Review of Clinical Psychology·Sara E TraceCynthia M Bulik
Feb 12, 2002·Pigment Cell Research·Joanne Voisey, Angela van Daal
Sep 11, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Deniz AtalayerAllan Geliebter
Apr 1, 2004·American Journal of Medical Genetics. Part a·Daniel L MarksRoger D Cone
Feb 9, 2010·Neuroscience and Biobehavioral Reviews·John K Young
May 23, 2008·Physiology & Behavior·J J G HillebrandR A H Adan
Jan 1, 2008·Physiology & Behavior·Walter Kaye
Jun 5, 2004·Biochemical and Biophysical Research Communications·Chantal CharbonneauGeorge Argyropoulos
Jul 15, 2015·The International Journal of Eating Disorders·Marek K BrandysRoger A H Adan
Jun 23, 2004·CNS Spectrums·David C Jimerson, Barbara E Wolfe
Apr 1, 2006·Physiology & Behavior·Jacquelien J G HillebrandRoger A H Adan
Feb 2, 2006·Journal of Affective Disorders·Regina C Casper
Dec 20, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jacquelien J G HillebrandRoger A H Adan
Jun 28, 2005·Peptides·Levi CarrollAngela van Daal
Jun 21, 2005·Peptides·Jacquelien J G HillebrandRoger A H Adan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.