Association between angiotensin-converting enzyme gene polymorphisms and exercise performance in patients with COPD

Respirology : Official Journal of the Asian Pacific Society of Respirology
Xiaolei ZhangJun Zhang

Abstract

Recent studies have shown that polymorphisms of the angiotensin-converting enzyme (ACE) gene are closely associated with pulmonary disorders. The ACE gene is involved in the regulation of inflammatory reactions to lung injury, respiratory drive, erythropoiesis and tissue oxygenation. The hypothesis for this study was that the ACE gene may be associated with the ventilatory response to exercise and the aerobic work efficiency of skeletal muscle in patients with COPD. Sixty-one Chinese Han COPD patients and 57 healthy control subjects performed incremental cardiopulmonary exercise testing on a cycle ergometer. ACE genotypes were determined using PCR amplification. Resting lung function and blood gas index were not significantly different among the three ACE genotype COPD groups. Similarly, there were no significant differences in AT, maximal O(2) uptake, maximal O(2) pulse, maximal dyspnoea index, ventilatory response (DeltaVE/DeltaVCO(2)), O(2) cost of ventilation (VO(2)/W/VE), end-tidal partial pressure of carbon dioxide at maximal exercise and maximal SaO(2) among the three ACE genotype COPD patients. Maximal work load and aerobic work efficiency were higher in the COPD group with the II genotype than in those with the ID or D...Continue Reading

References

Jul 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·M WicklmayrH Mehnert
Jan 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B J WhippK Wasserman
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·J SauledaA G Agusti
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·P JakobssonJ Henriksson
Jun 2, 1998·Nature·H E MontgomeryS E Humphries
Feb 25, 2000·Nature·A G WilliamsH E Montgomery
Jul 6, 2000·European Journal of Applied Physiology·R AlvarezE Coto
Oct 9, 2002·Medicine and Science in Sports and Exercise·Frits M E FranssenAnnemie M W J Schols
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Robert M Ross
Jul 2, 2003·Thorax·R Forth, H Montgomery
Nov 19, 2003·The European Respiratory Journal·S PatelA J Peacock
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Aug 5, 2004·Medicine and Science in Sports and Exercise·Malcolm CollinsTimothy D Noakes
Sep 9, 2004·Medicine and Science in Sports and Exercise·Tuomo RankinenClaude Bouchard

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Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin R J Kolb, Ian Yang
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Elaine A OstranderGary K Ostrander
Oct 12, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Yohan Bossé
May 28, 2011·Sports Medicine·Zudin PuthuchearyHugh E Montgomery
Oct 8, 2014·Chest·Michael C Steiner, Neil J Greening
Sep 3, 2010·Pediatric Pulmonology·Gabriel DimitriouStefanos Mantagos
May 25, 2013·Respiratory Medicine·Natalia A KuzubovaOlga N Titova
Apr 12, 2014·BioMed Research International·Cheryl R Laratta, Stephan van Eeden
Jun 2, 2016·American Journal of Respiratory and Critical Care Medicine·Katrina J CurtisNicholas S Hopkinson
May 3, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Guodong XuWenquan Niu
Jul 14, 2010·European Journal of Medical Research·S PabstC Grohé
Sep 9, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Teng HanXiao Lei Zhang
Sep 1, 2010·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Barbara J Nicklas

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