PMID: 9180368Jan 1, 1997Paper

Association between angiotensin converting enzyme gene polymorphism and clinical features in autosomal dominant polycystic kidney disease

Life Sciences
J UemasuS Morio

Abstract

We investigated the association between angiotensin converting enzyme (ACE) gene polymorphism and clinical manifestations in 47 patients with autosomal dominant polycystic kidney disease (ADPKD). One-hundred, age- and sex-matched subjects with non-ADPKD served as the controls. ACE gene polymorphism was analysed using a GeneAnp kit. Renal size was determined by abdominal CT scan, by adding the longitudinal axis of each kidney. Incidence of extrarenal complication was also examined. Out of 47 patients, 24 patients (51%) were II, 18 (38%) ID and 5 (11%) DD type. The frequencies of the I and D alleles as well as the distributions of ACE genotypes in ADPKD did not differ from those in controls. The number of patients undertaking renal replacement therapy was 11 in II (46%), 6 (33%) in ID and 2 (40%) in DD genotype, respectively, that was not significantly different among the groups. The mean age of the initiation of renal replacement therapy did not vary among the three genotypes. The slopes of 1/serum creatinine did not differ between II and ID genotypes, whose initial serum creatinine levels ranged from 1.5 to 2.5 mg/dl. Renal size, blood pressure, and extrarenal complications including liver cysts and cardiac valvular disease wer...Continue Reading

Citations

Jun 9, 1998·Current Opinion in Nephrology and Hypertension·A G JardineJ M Connell
Dec 29, 2000·Current Opinion in Nephrology and Hypertension·M W Taal
Mar 23, 2005·Kidney International·Pamela R FainRobert W Schrier
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T KonoshitaH Mabuchi
Aug 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tiago Veiga PereiraJosé Eduardo Krieger
Apr 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Melissa A CadnapaphornchaiRobert W Schrier
Jul 31, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Bjarne OrskovSvend Strandgaard
Sep 10, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ronald D PerroneCatherine M Meyers
Jan 23, 2008·Genetical Research·Y B SaabA D J Overall
Dec 26, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T SchiavelloM Thomas
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·M A van DijkP C Chang
Aug 4, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L Pérez-OllerA Darnell

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