Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Nina Liu, Youmin Wang

Abstract

Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN. We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI). In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84-1.75; MM vs TT: OR = 1.94, 95% CI = 0.93-4.04; MT vs TT: OR = 1.11, 95% CI = 0.76-1.63; the dominant model: OR =1.19, 95% CI = 0.80-1.77; the recessive model: OR = 1.94, 95% CI = 0.93-4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians. Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A SoliniR Nosadini
May 28, 2003·Journal of Clinical Epidemiology·John AttiaCatherine D'Este
Dec 25, 2007·Experimental Biology and Medicine·Yashpal S KanwarFarhad R Danesh
Jul 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mitsuo KatoRama Natarajan
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
May 5, 2010·Nature Reviews. Nephrology·Piero RuggenentiGiuseppe Remuzzi
Dec 15, 2010·Kidney International·Caitrin W McDonoughDonald W Bowden
Mar 23, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nabil MtiraouiWassim Y Almawi
Oct 3, 2012·PLoS Genetics·Niina SandholmAlexander P Maxwell
Dec 4, 2013·Nature Reviews. Nephrology·Sara S RoscioniDick de Zeeuw
Dec 24, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsLawrence Agodoa
Jun 20, 2014·Comprehensive Physiology·Matthew A SparksThomas M Coffman
Jan 31, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yong-Chao QiaoHai-Lu Zhao

❮ Previous
Next ❯

Citations

Sep 24, 2020·The Journal of International Medical Research·Feng ZhangChunping Ni
Jan 12, 2021·Journal of Diabetes and Its Complications·Miguel Vázquez-MorenoAdan Valladares-Salgado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.