Association between anti-acid therapies and advanced fibrosis in type 2 diabetics with biopsy-proven non-alcoholic fatty liver disease.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Amandeep SinghNaim Alkhouri

Abstract

Data on associations of antacid therapies with advanced fibrosis (AF) in patients with non-alcoholic fatty liver disease (NAFLD) are limited. We aimed to assess the association of histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with AF in NAFLD patients with underlying type 2 diabetes (T2D). We retrospectively reviewed patient's charts with T2D who had a liver biopsy for suspected NAFLD. Fibrosis stages were determined as F0-F4, AF being F3-4. Laboratory data and use of various medications within 24 months of liver biopsies were used for the analysis. Univariable and multivariable logistic regression analyses were performed to assess any association. Our cohort consisted of 1008 T2D patients with biopsy-proven NAFLD. Sixty-six percent were female, 86.2% were Caucasian, and median HbA1C was 6.4%. AF was present in 32% of the patients. Thirty-four percent were on H2RAs and 60.6% were on PPI therapy (p < 0.001) for a median duration of 3.6 [0.10, 3.8] (p = 0.20) and 45.6 [0.80, 15.4] (p = 0.17) months, respectively. On multivariable logistic regression analysis being on H2RAs was associated with a 68% lower risk of AF (odds ratio [OR] [95%CI]: 0.32 [0.24, 0.44]) (p < 0.001), but use of PPIs showed a tren...Continue Reading

References

Jul 10, 2004·Journal of Gastroenterology and Hepatology·Parijat Gupte Hafeezunnisa
Oct 21, 2006·The Cochrane Database of Systematic Reviews·P MoayyediD Forman
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe
Apr 4, 2008·Journal of the American Society of Nephrology : JASN·Giovanni TargherMichele Muggeo
Oct 29, 2008·Seminars in Liver Disease·Mariana Lazo, Jeanne M Clark
Apr 11, 2009·Gut·A MencinR F Schwabe
Jan 12, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lucio LombardoAndrea Chiecchio
Jul 29, 2010·Seminars in Liver Disease·Jean-Philippe PradereRobert F Schwabe
May 17, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yanfei ChenLanjuan Li
Oct 18, 2011·Alimentary Pharmacology & Therapeutics·C Bavishi, H L Dupont
Nov 9, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heather L FrancisPaolo Onori
Feb 3, 2012·Nature·Jorge Henao-MejiaRichard A Flavell
Sep 12, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca MieleAntonio Grieco
Dec 29, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wai-Kit Lo, Walter W Chan
Jan 29, 2013·World Journal of Hepatology·Paschalis Paschos, Konstantinos Tziomalos
Aug 21, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander WreeAriel E Feldstein
Nov 14, 2013·Journal of Gastroenterology and Hepatology·Jee Hye KwonHyun Chae Jung
Jul 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekihiro Seki, Robert F Schwabe
Dec 4, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Magdalena MazagovaBernd Schnabl
Mar 18, 2015·World Journal of Gastroenterology : WJG·Xiao-Meng SunLin Lin
Dec 15, 2015·Gut·Floris ImhannAlexandra Zhernakova
Jan 1, 2016·Gut·Matthew A JacksonClaire J Steves
Jan 12, 2016·JAMA Internal Medicine·Benjamin LazarusMorgan E Grams
Sep 7, 2017·European Journal of Nutrition·Fabiana de Faria GhettiAna Paula Boroni Moreira
Jul 22, 2018·Hepatology Communications·Naim AlkhouriEric Lawitz
Aug 3, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Amandeep SinghDonald F Kirby
Aug 17, 2018·European Journal of Gastroenterology & Hepatology·Dunya TomicStuart K Roberts
Oct 27, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiko SawadaHitoshi Yoshiji

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Citations

Jan 20, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Jimmy K Limdi
Jun 23, 2021·Expert Review of Gastroenterology & Hepatology·Jiarong LinZhijun Duan

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