Association Between Antibiotic Exposure, Bronchiolitis, and TLR4 (rs1927911) Polymorphisms in Childhood Asthma

Allergy, Asthma & Immunology Research
Eun LeeSoo-Jong Hong

Abstract

The complex interplay between environmental and genetic factors plays an important role in the development of asthma. Several studies have yielded conflicting results regarding the 2 asthma-related risk factors: antibiotic usage during infancy and/or a history of bronchiolitis during early life and the development of asthma. In addition to these risk factors, we also explored the effects of Toll-like receptor 4 (TLR4) polymorphism on the development of childhood asthma. This cross-sectional study involved 7,389 middle school students who were from 8 areas of Seoul, Korea, and completed the International Study of Asthma and Allergies in Childhood questionnaire. The TLR4 polymorphism rs1927911 was genotyped in 1,395 middle school students from two areas using the TaqMan assay. Bronchiolitis in the first 2 years of life, antibiotic exposure during the first year of life, and parental history of asthma were independent risk factors for the development of asthma. When combined, antibiotic use and a history of bronchiolitis increased the risk of asthma (adjusted odds ratio [aOR]: 4.64, 95% confidence interval [CI]: 3.09-6.97, P value for interaction=0.02). In subjects with CC genotype of TLR4, antibiotic exposure and a history of bro...Continue Reading

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Jan 24, 2016·Current Treatment Options in Gastroenterology·Elizabeth T Jensen, Randi J Bertelsen
Jun 12, 2017·The Journal of Allergy and Clinical Immunology·Elizabeth T JensenEvan S Dellon
Mar 21, 2019·Allergy·Kazuhiko MaedaShizuo Akira
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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS

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