Association between Antibiotic Use and Hospital-Onset Clostridioidesdifficile Infection in U.S. Acute Care Hospitals, 2006-2012: an Ecologic Analysis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sophia V KazakovaJohn A Jernigan

Abstract

Unnecessary antibiotic use (AU) contributes to increased rates of Clostridioides difficile Infection (CDI). The impact of antibiotic restriction on hospital-onset CDI (HO-CDI) has not been assessed in a large group of U.S. acute care hospitals (ACHs). We examined cross-sectional and temporal associations between rates of hospital-level AU and HO-CDI using data from 549 ACHs. HO-CDI, a discharge with a secondary ICD-9-CM for CDI (008.45) and treatment with metronidazole or oral vancomycin ≥ 3 days after admission. Analyses were performed using multivariable generalized estimating equation models adjusting for patient and hospital characteristics. During 2006-2012, the unadjusted annual rates of HO-CDI and total AU were 7.3 per 10,000 patient-days (PD) (95% CI: 7.1-7.5) and 811 days of therapy (DOT)/1,000 PD (95% CI: 803-820), respectively. In the cross-sectional analysis, for every 50 DOT/1,000 PD increase in total AU, there was a 4.4% increase in HO-CDI. For every 10 DOT/1,000 PD increase in use of third- and fourth-generation cephalosporins or carbapenems there was a 2.1% and 2.9% increase in HO-CDI, respectively. In the time-series analysis, the 6 ACHs with a ≥ 30% decrease in total AU had a 33% decrease in HO-CDI (rate ratio...Continue Reading

References

May 15, 2003·The Journal of Antimicrobial Chemotherapy·Claudia ThomasThomas V Riley
May 28, 2004·The Journal of Antimicrobial Chemotherapy·Mark H WilcoxOliver Corrado
Dec 3, 2005·The New England Journal of Medicine·L Clifford McDonaldDale N Gerding
Dec 13, 2006·Archives of Internal Medicine·Sophia V KazakovaL Clifford McDonald
Feb 1, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L Clifford McDonaldUNKNOWN Ad Hoc Clostridium difficile Surveillance Working Group
Aug 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis ValiquetteJacques Pépin
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C OwensCarlene A Muto
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R DubberkeVictoria J Fraser
Jan 27, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erik R DubberkeUNKNOWN Prevention Epicenters Program of the Centers for Disease Control and Prevention
Jan 7, 2011·Journal of Clinical Epidemiology·Joshua J GagneSebastian Schneeweiss
Aug 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolyn V GouldUNKNOWN Clostridium difficile Infection Surveillance Investigators, Centers for Disease Control and Prevention
Dec 11, 2013·The Journal of Antimicrobial Chemotherapy·Claudia Slimings, Thomas V Riley
Mar 19, 2014·The Journal of Antimicrobial Chemotherapy·Leah M FeazelMarin L Schweizer
Mar 29, 2014·The New England Journal of Medicine·Shelley S MagillUNKNOWN Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
May 29, 2014·British Journal of Clinical Pharmacology·Joao B PereiraJonathan Jonathan Cooke
Jan 18, 2015·Infectious Disease Clinics of North America·Curtis J DonskeyAbhishek Deshpande
Jan 31, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michael J DurkinRebekah W Moehring
Feb 26, 2015·The New England Journal of Medicine·Fernanda C LessaL Clifford McDonald
Mar 4, 2015·The American Journal of Gastroenterology·Ioannis M ZacharioudakisEleftherios Mylonakis
May 20, 2015·Antimicrobial Agents and Chemotherapy·Erik R DubberkeCarey-Ann D Burnham
Oct 22, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nicola D ThompsonShelley S Magill
Sep 23, 2016·JAMA Internal Medicine·James BaggsJohn A Jernigan
Jan 29, 2017·The Lancet Infectious Diseases·Kate E DingleUNKNOWN Modernising Medical Microbiology Informatics Group
Mar 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L Clifford McDonaldMark H Wilcox
Apr 13, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gregory R MaddenKyle B Enfield

❮ Previous
Next ❯

Citations

Nov 26, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kevin A BrownNick Daneman
Oct 5, 2019·BMJ Quality & Safety·Susy S HotaGonzalo Bearman
Jun 5, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michelle E DollGonzalo Bearman
May 30, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Julia E SzymczakUNKNOWN CDC Prevention Epicenters Program
May 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katherine E GoodmanAnthony D Harris
Sep 17, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ying P TabakL Clifford McDonald
Apr 4, 2020·The New England Journal of Medicine·Alice Y GuhUNKNOWN Emerging Infections Program Clostridioides difficile Infection Working Group
Sep 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James C Hurley
Oct 31, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Michelle DollVictor D Rosenthal
Dec 31, 2020·Antibiotics·José Francisco García-RodríguezAna Mariño-Callejo
Dec 9, 2020·Journal of Korean Medical Science·Bongyoung KimHyunjoo Pai
Apr 16, 2021·Prehospital and Disaster Medicine·Cody Vaughn GibsonGeorge Donald Collier
Jan 25, 2020·Expert Review of Anti-infective Therapy·Adriana M RauseoErik R Dubberke
May 8, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sophia V KazakovaL Clifford McDonald
May 21, 2021·The Journal of Antimicrobial Chemotherapy·Daniel J LivorsiUNKNOWN Veterans Affairs-Centers for Disease Control and Prevention Practice-Based Research Network
Jun 27, 2021·The International Journal of Pharmacy Practice·Amy Kruger HowardJill A Morgan
May 28, 2021·Current Opinion in Infectious Diseases·Anna StachelUNKNOWN CDC MInD Healthcare Program
Aug 28, 2021·Pharmacy : Journal of Pharmacy, Education and Practice·Mary E SheffieldChristopher M Bland
Oct 13, 2021·Annals of Intensive Care·Guylaine LabroUNKNOWN PROPASPI (PROcalcitonin Pneumonia/pneumonitis Associated with ASPIration) trial investigators
Sep 30, 2021·Experimental and Therapeutic Medicine·Simona SiposVlad Predescu
Nov 19, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerie M VaughnScott A Flanders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Related Papers

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Alexander J KallenL Clifford McDonald
Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine
Tara LaguPeter K Lindenauer
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Amy L PakyzRonald E Polk
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Timothy C JenkinsPhilip S Mehler
© 2022 Meta ULC. All rights reserved