PMID: 16618009Apr 19, 2006Paper

Association between antidepressant use and prescribing of gastric acid suppressants

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
Janice MaJohn Sampalis

Abstract

To determine whether an increased risk of gastrointestinal events is present in younger, generally healthy adults who consume antidepressants. We performed a retrospective cohort study using the pharmacy records of Canadian Forces (CF) members who received antidepressants between June 1997 and November 2002, excluding those taking bupropion for smoking cessation. The control cohort comprised members who received salbutamol. Changes in use of gastric acid-reducing agents (GARs) and incident GAR prescribing rates were compared pre- and postinitiation of target medications. We performed ogistic regression analyses to evaluate the effects of age, sex, and concomitant medication use on GAR prescribing. A total of 8722 antidepressant exposures were identified among 5588 CF members. The control cohort consisted of 3059 people with 4154 salbutamol exposures. The number of incident GAR prescriptions decreased in both groups postexposure; however, the rate of decrease was significantly greater among salbutamol users (odds ratio 1.38; 95%CI, 1.12 to 1.71). Antidepressant users were significantly more likely to receive a new prescription for GAR following both short-term and long-term exposure (adjusted odds ratio 4.93; 95%CI, 2.66 to 9.21...Continue Reading

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Citations

Nov 16, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I T PadolR H Hunt
Jul 3, 2008·Digestion·D PohlUNKNOWN Kandahar Study Group

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