Abstract
Published data have suggested a correlation between antifungal prophylaxis and bacteremia in febrile neutropenia. This correlation was investigated among 3002 febrile neutropenic patients enrolled in 4 trials during 1986-1994. Globally, 1322 patients (44%) did not receive antifungal prophylaxis; 835 (28%) received poorly absorbable antifungal agents and 845 (28%) received absorbable antifungal agents. The rates of bacteremia for these groups were 20%, 26%, and 27%, respectively (P=.0001). In a multivariate model without including antifungal prophylaxis, factors associated with bacteremia were: age, duration of hospitalization, duration of neutropenia before enrollment, underlying disease, presence of an intravenous catheter, shock, antibacterial prophylaxis, temperature, and granulocyte count at onset of fever. When antifungal prophylaxis was included, the adjustment quality of the model improved slightly (P=.05), with an odds ratio of 1.19 (95% confidence interval [CI], 0.92-1.55) for patients receiving nonabsorbable and 1.42 (95% CI, 1.07-1.88) for those who were receiving absorbable antifungal agents. Antifungal prophylaxis with absorbable agents might have an impact on the rate of documented bacteremia in febrile neutropeni...Continue Reading
References
Mar 26, 1992·The New England Journal of Medicine·J L GoodmanD J Friedman
Apr 1, 1992·Journal of Internal Medicine·J PalmbladG Oberg
Dec 31, 1987·The New England Journal of Medicine·UNKNOWN EORTC International Antimicrobial Therapy Cooperative GroupS H Zinner
Oct 1, 1995·The Journal of Infectious Diseases·A Schaffner, M Schaffner
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·A ComettaM P Glauser
Jun 1, 1995·The Journal of Infectious Diseases·M A SlavinR A Bowden
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C ViscoliJ Klastersky
Oct 1, 1993·Annals of Internal Medicine
May 1, 1996·Antimicrobial Agents and Chemotherapy·A ComettaM P Glauser
Mar 4, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F MenichettiF Mandelli
Citations
Jan 13, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y-K ChenH-F Tien
Nov 22, 2007·Wiener medizinische Wochenschrift·Philipp StaberPeter Neumeister
Nov 5, 2002·Critical Reviews in Oncology/hematology·C S M Oude NijhuisEveline S J M de Bont
Jul 24, 2008·Bone Marrow Transplantation·E CastagnolaC Viscoli
Sep 12, 1998·British Journal of Haematology·C Viscoli, E Castagnola
Apr 26, 2002·British Journal of Haematology·Nicole M A BlijlevensBen E de Pauw
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R P WenzelM B Edmond
Dec 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudio ViscoliUNKNOWN International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer
Jan 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine CordonnierUNKNOWN Club de Réflexion sur les Infections en Onco-Hématologie
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Murat AkovaUNKNOWN International Antimicrobial Therapy Group of the European Organization for Research and Treatment of Cancer
Dec 11, 2013·Haematologica·Diana AverbuchUNKNOWN ECIL4, a joint venture of EBMT, EORTC, ICHS, ESGICH/ESCMID and ELN
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kent A Sepkowitz
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E CastagnolaC Viscoli
Jan 29, 2008·European Journal of Haematology·Anne NihtinenTapani Ruutu
Jul 15, 2011·European Journal of Haematology·Oliver A CornelyCarlos Vallejo
Mar 7, 2014·Stem Cells Translational Medicine·Marion E G Brunck, Lars K Nielsen
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Feb 2, 2006·The Journal of Antimicrobial Chemotherapy·C CharlierO Lortholary
Aug 23, 2019·Journal of Medical Microbiology·Matthaios Papadimitriou-OlivgerisMarkos Marangos
Oct 24, 2002·Blood·Oliver A CornelyMeinolf Karthaus
Jul 20, 2002·Current Opinion in Infectious Diseases·Claudio Viscoli, Elio Castagnola
Oct 7, 2020·Scientific Reports·Emese TolnaiMelinda Paholcsek