PMID: 9550329Apr 29, 1998Paper

Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8

Tissue Antigens
C B SanjeeviG Dahlquist

Abstract

HLA DQA1*0301-DQB1*0302 (DQ8) and DQA1*0501-DQB1*0201 (DQ2) are positively and DQA1*0102-DQB1*0602 (DQ6) negatively associated with IDDM. In DQA1*0301-DQB1*0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1*0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as ICA in 425 Swedish children with IDDM and 367 controls in the age group of 0-15 years. We found that ICA512 autoantibodies were associated primarily with DRB1*0401 and not with DQA1*0301-DQB1*0302 (DQ8). No such hierarchy could be demonstrated for insulin autoantibodies, which were associated with both DQA1*0301-DQB1*0302 (DQ8) and DRB1*0401. GAD65 autoantibodies, known to be closely associated with DQA1*0501-DQB1*0201 (DQ2)-DRB1*0301 haplotype, also showed no preferential association with DQA1*0301-DQB1*0302 (DQ8) versus DRB1*04. These results suggest that the immune response to different beta-cell autoantigens may be mediated via HLA class II molecules from different loci. Design of the antigen-specific immuno-intervention trials should take into account these HLA-DR and DQ subtype associations.

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Citations

Dec 10, 1999·The Journal of Clinical Investigation·A Lernmark
May 22, 2002·Annals of the New York Academy of Sciences·A Shtauvere-BrameusC B Sanjeevi
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Karin LarssonAke Lernmark
Feb 9, 2005·Annals of the New York Academy of Sciences·Liene Nikitina-ZakeCarani B Sanjeevi
Feb 9, 2005·Annals of the New York Academy of Sciences·Yongsoo ParkIan R Mackay
Nov 30, 2006·Annals of the New York Academy of Sciences·Carani B Sanjeevi
Apr 8, 2010·European Journal of Endocrinology·W L AwaUNKNOWN DPV-Wiss Study Group and the German Competence Network Diabetes Mellitus
Oct 30, 2015·Genes and Immunity·M MaziarzUNKNOWN Type 1 Diabetes Genetics Consortium
Apr 30, 2002·Diabetes·Jinko GrahamUNKNOWN Swedish Childhood Diabetes Study Group
Dec 3, 2008·International Journal of Immunogenetics·A ShastryC B Sanjeevi
Mar 23, 2011·Pediatric Diabetes·Rebecca B LiptonWilliam A Hagopian
Jan 6, 2009·Annals of the New York Academy of Sciences·Carani B SanjeeviUNKNOWN Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups
Jan 1, 2015·Expert Review of Endocrinology & Metabolism·Jorma IlonenOuti Vaarala

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