Abstract
Hydroxychloroquine sulfate is a commonly used medication for patients with dermatomyositis and has been associated with a uniquely elevated risk of adverse cutaneous reactions in this population. No studies to date have examined whether certain subsets of patients with dermatomyositis are at increased risk of experiencing a hydroxychloroquine-associated skin eruption. To identify disease features that increase the risk of hydroxychloroquine-associated skin eruption in adults with dermatomyositis. A retrospective cohort study was conducted in the outpatient dermatology clinic at a tertiary academic referral center. All adults with dermatomyositis (age >18 years) who started receiving hydroxychloroquine between July 1, 1990, and September 13, 2016, were eligible for the analysis. Patients were considered to have a hydroxychloroquine-associated skin eruption if a skin eruption had developed within their first 4 weeks of treatment and resolved with discontinuation of hydroxychloroquine therapy. One or more doses of hydroxychloroquine. The associations between autoantibodies (against transcription intermediary factor 1γ [TIF-1γ], nucleosome-remodeling deacetylase complex [Mi-2], nuclear matrix protein [NXP-2], small ubiquitinlike mo...Continue Reading
References
Feb 20, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Apr 1, 1984·Journal of the American Academy of Dermatology·T Y WooC Hawkins
Aug 13, 2002·Dermatologic Clinics·Richard D Sontheimer
Sep 13, 2002·Archives of Dermatology·Michelle T Pelle, Jeffrey P Callen
Jul 20, 2005·Archives of Dermatology·Gina Charlene Ang, Victoria P Werth
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alenka KuznikRoman Jerala
Aug 14, 2012·Arthritis and Rheumatism·Ann M ReedEmily Baechler Gillespie
Dec 22, 2012·Science·Lijun SunZhijian J Chen
Sep 17, 2013·Arthritis and Rheumatism·David F FiorentinoLivia Casciola-Rosen
Mar 31, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie AnKeith B Elkon
May 23, 2015·The British Journal of Dermatology·C O AnyanwuV P Werth
Aug 27, 2016·The British Journal of Dermatology·C HuardS A Greenberg
Nov 5, 2016·Annual Review of Medicine·Jie AnKeith B Elkon
Nov 9, 2017·JAMA Dermatology·Paige W WolstencroftDavid F Fiorentino
Citations
Feb 26, 2020·American Journal of Clinical Dermatology·Gabriela A CobosRuth Ann Vleugels
Jul 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·S Chavez-AlvarezJ Ocampo-Candiani
Jan 31, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Alina DimaLaurent Arnaud
Jun 11, 2020·Current Drug Metabolism·Cheng CuiDongyang Liu
Feb 20, 2021·Journal of the American Academy of Dermatology·Andressa L Akabane, Gideon P Smith
Mar 29, 2021·ACR Open Rheumatology·Jemima AlbaydaLisa Christopher-Stine
Apr 13, 2021·Arthritis & Rheumatology·Ingrid E Lundberg