Association between AUTS2 haplotypes and alcohol dependence in a Japanese population

Acta Neuropsychiatrica
Shin NaritaKazuhiko Iwahashi

Abstract

Recent genome-wide analysis has indicated that the autism susceptibility candidate 2 (AUTS2) gene is involved in the regulation of alcohol consumption. We hypothesised that AUTS2 might be associated with the development of alcohol dependence. Therefore, in this exploratory study, we compared the genotype and allele frequencies of the polymorphisms rs6943555 and rs9886351 in the AUTS2 gene between patients with alcohol dependence and healthy control subjects living in a Japanese provincial prefecture. We also examined whether or not the haplotypes consisting of these polymorphisms are related to alcohol dependence. The subjects of this study consisted of 64 patients with alcohol dependence and 75 unrelated healthy people. The AUTS2 genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. No significant differences in the genotype and allele frequencies of the polymorphisms AUTS2 rs6943555 and rs9886351 were found between alcohol dependence and control subjects. On the other hand, the frequencies of the AUTS2 haplotypes were significantly different between them, and the rs6943555 and rs9886351 A-A haplotype was associated with alcohol dependence (p=0.0187). This sugg...Continue Reading

References

May 16, 1998·BMJ : British Medical Journal·T V Perneger
Mar 29, 2001·Current Psychiatry Reports·M A Enoch, D Goldman
Oct 18, 2002·Genetic Epidemiology·Richard W Morris, Norman L Kaplan
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Marc A SchuckitJelger Kalmijn
Jul 5, 2005·Nature Reviews. Genetics·David GoldmanFrancesca Ducci
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Mar 8, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertAnup Madan
Apr 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gunter SchumannPaul Elliott
Sep 22, 2012·Drug and Alcohol Dependence·Yun-Hsiang ChenChia-Hsiang Chen
Sep 7, 2013·Trends in Genetics : TIG·Nir Oksenberg, Nadav Ahituv
Oct 28, 2014·International Journal of Molecular Sciences·Bao ZhangSheng-Bin Li

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Sep 17, 2020·International Journal of Molecular Sciences·Daniel R LathenAdrian Rothenfluh

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