Association between background exposure to organochlorine pesticides and the risk of cognitive impairment: A prospective study that accounts for weight change

Environment International
Duk-Hee LeeLars Lind

Abstract

Background exposure to organochlorine (OC) pesticides was recently linked to cognitive impairment and dementia in cross-sectional and case-control studies. This prospective study was performed to evaluate if OC pesticides at baseline are associated with the future risk of cognitive impairment in elderly, with particular focus on weight change. Plasma concentrations of 3 OC pesticides (p,p'-DDE, trans-nonachlor, and hexachlorobenzene) were measured among 989 men and women aged 70years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Cognitive impairment was validated by reviewing medical records. During the ten year follow-up, cognitive impairment was developed in 75 subjects. When weight change from age 70 to 75 was considered in analyses, elderly with incident cases before age 75 were excluded to keep the prospective perspective, leaving 795 study subjects and 44 incident cases. The summary measure of 3 OC pesticides predicted the development of cognitive impairment after adjusting for covariates, including weight change. Compared to subjects with OC pesticides <25th percentile, adjusted hazard ratios (HRs) in those with 25th-<75th and ≥75th percentiles were 3.5 (95% confidence interval: 1.5-8.5)...Continue Reading

References

Jul 1, 1989·Archives of Environmental Contamination and Toxicology·D L PhillipsL L Needham
Oct 1, 1996·Journal of the American Geriatrics Society·E Barrett-ConnorW C Wiederholt
Jan 5, 1999·Environmental Health Perspectives·B E Fisher
Aug 6, 2003·Neurotoxicology·C ColosioM Maroni
Sep 28, 2005·Neurology·A S BuchmanD A Bennett
Nov 24, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P IrigarayD Belpomme
Dec 2, 2008·Journal of Nutrition for the Elderly·Karen L Smith, Carol E Greenwood
Sep 8, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J S LimD-H Lee
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K J AnsteyJ Young
Apr 5, 2012·Atherosclerosis·Jérôme RuzzinDavid R Jacobs
Jan 30, 2014·JAMA Neurology·Jason R RichardsonDwight C German
May 23, 2014·Environment International·Thierry Comlan Marc MedehouenouDanielle Laurin

❮ Previous
Next ❯

Citations

Sep 12, 2016·The Science of the Total Environment·Ki-Hyun KimShamin Ara Jahan
Dec 3, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y-M LeeD-H Lee
Mar 10, 2017·International Journal of Hygiene and Environmental Health·Juan José RamosUNKNOWN Bioambient.es
Aug 16, 2018·Reviews on Environmental Health·Banrida Wahlang
Dec 9, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ki-Su KimDuk-Hee Lee
Oct 12, 2017·Environmental Health : a Global Access Science Source·Kristiann Fry, Melinda C Power
Dec 16, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandeep KumarKi-Hyun Kim
Mar 8, 2020·Toxicology Letters·Athina-Maria AloizouEfthimios Dardiotis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.