Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Qian WangZhuoyou Chen

Abstract

Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cognitive processes, and cognitive impairment in Parkinson's disease (PD), but with contradictory findings. Thus, this meta-analysis was performed to clarify the possible association. Relevant studies were identified by a systematic search of PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases. The strength of the association was evaluated using crude odds ratios and 95% confidence interval. Finally, six studies involving 532 cases and 802 controls were included. Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. In conclusion, BDNF G196A (Val66Met) is confirmed to be a risk factor for cognitive impairment in PD.

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Citations

Mar 12, 2020·Antioxidants & Redox Signaling·Inês Marques-AleixoJosé Magalhães
Dec 18, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Maopeng WangXinzhi Li
Oct 25, 2020·International Journal of Molecular Sciences·Luca Colucci-D'AmatoFloriana Volpicelli
Feb 21, 2021·Molecular Neurobiology·Efthalia AngelopoulouChristina Piperi
Dec 4, 2020·Aging and Disease·Rodrigo Urbina-VarelaAndrea Del Campo

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