Association between biomarkers of carbonyl stress with increased systemic inflammatory response in different stages of chronic kidney disease and after renal transplantation

Nephron. Clinical Practice
Paulo R AvelesRoberto Pecoits-Filho

Abstract

Chronic kidney disease (CKD) is characterized by progressive kidney dysfunction accompanied by accumulation of uremic toxins and a potential disequilibrium between the redox status and the generation of prooxidants, resulting in oxidative stress and chronic inflammation which is associated with complications (particularly cardiovascular disease) in this population. We aimed to analyze the concentration of total plasma thiols (indicator of antioxidant capacity) and the protein carbonyl content (a marker of carbonyl stress) in relation to kidney function and inflammation in a group of patients with CKD. A group of 68 patients with CKD (stages 2-5; mean age 57 ± 12 years, 46% male, 34% diabetics) and another group of 21 patients who underwent living donor kidney transplantation (mean age 36 ± 17 years, 50% male, 10% diabetics, and 9 ± 2 months after renal transplantation) were included in the study. Total plasma thiol and protein carbonyl levels were determined by the DTNB and DNPH methods, respectively, and were adjusted to the plasma albumin concentrations. Plasma levels of fibrinogen and C-reactive protein (CRP) were measured by routine methods and used as markers of inflammation. Mean glomerular filtration rate (GFR) was 48 ml...Continue Reading

Citations

Jan 24, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick Steven TuckerMichael Ian Kingsley
Jan 5, 2016·Biological & Pharmaceutical Bulletin·Teppei TakahashiSeiichi Era
Jun 18, 2015·Redox Report : Communications in Free Radical Research·Lei Zhang On Behalf Of The Hero Study Collaborative Group
Feb 25, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elani StrejaMoti L Kashyap
Mar 19, 2014·Leukemia Research·Alexander Sidelmann ChristensenHans Carl Hasselbalch
May 13, 2017·Redox Report : Communications in Free Radical Research·Larissa Vieira MarinoPaula Garcia Chiarello
Dec 8, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Natalia KrataKrzysztof Mucha
Mar 8, 2018·Seminars in Dialysis·Kristen L Nowak, Michel Chonchol
Nov 7, 2019·Clinical Hemorheology and Microcirculation·Gregorio CaimiRosalia Lo Presti
Oct 20, 2018·Journal of Clinical Medicine·Simona AdessoStefania Marzocco
Oct 5, 2018·Rheumatology·Jessica L TurnierBruce Aronow
Jun 11, 2020·Journal of the American Society of Nephrology : JASN·Nans FlorensChristophe O Soulage
May 4, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cem Yasar SanhalAykan Yucel
Feb 23, 2020·Oxidative Medicine and Cellular Longevity·Marianna GyurászováĽubomíra Tóthová
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie Hilderman, Annette Bruchfeld
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Graziano ColomboIsabella Dalle-Donne
Aug 14, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Refat NimerLina A Dahabiyeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.